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|本期目录/Table of Contents|

不同类型冠心病患者血清sCD40L水平及其临床意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第2期
页码:
213-215
栏目:
临床研究
出版日期:
2008-03-20

文章信息/Info

Title:
Clinical significance of serum sCD40L changes in patients with different types of coronary heart diseases
作者:
陈颖敏; 徐瑾; 李洪波; 应小盈; 宋玮; 丁鸿毅; 谢秀兰; 王彬尧; 何奔
上海交通大学医学院附属仁济医院心内科，上海 200001
Author(s):
Chen yingmin;  XU Jin;  Li hongbo;  Ying xiaoying;  Song wei;  Ding hongyi;  XIE Xiulan;  Wang binyao;  He ben
Renji Hospital, Shanghai Jiaotong University Medical School, Shanghai 200001, China
关键词:
血清可溶性 CD4OL; 冠状动脉疾病; 生物标志物
Keywords:
serum soluble CD40 ligand;  coronary disease;  marker
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨不同类型冠状动脉粥样硬化性心脏病患者中的血清可溶性 CD4OL (sCD40L)水平的变化及其临床意义。方法 本研究采用酶联免疫吸附法，对正常对照组25例, 稳定型心绞痛(SA) 25 例,急性冠脉综合征(ACS)50例［其中包括不稳定型心绞痛(UA)29例,急性心肌梗死(AMI)21例］的血清 sCD40L 水平进行检测。结果 ①ACS 组血清 sCD40L 水平明显比 SA组和对照组高 (P<0.01)；②AMI组与UA组血清 sCD40L 水平比较两者无统计学差异；③SA组与对照组相比无统计学差异；④SA发展为UA时sCD40L显著升高。结论 sCD40L 升高在 ACS 的发生发展中具有极其重要的作用,sCD40L升高可作为不稳定动脉粥样硬化班块的一个检测指标。
Abstract:
AIM To investigate the clinical significance of serum soluble CD40L (sCD40L) changes in patients with different types of coronary heart diseases. METHODS Twentyfive normal subjects made up the control group and 75 patients, including 25 with stable angina pectoris (SA), 29 with unstable angina pectoris (UA) and 21 with acute myocardial infarct (AMI) were enrolled in this study. The serum sCD40L levels were measured by ELISA. RESULTS ①sCD40L levels were significantly higher in patients with acute coronary syndrome (ACS)； ②The serum sCD40L levels in UA patients and AMI patients were higher compared with those with SA and those in control group (P<0.01), with no significant difference between AMI and UA and between SA and control group； ③The serum sCD40L was significantly higher when SA deteriorated to UA. CONCLUSION The increasing levels of sCD40L may play an important role in ACS, which can be used as a potential marker of plaque instability.

参考文献/References

［1］ Ross R．The pathogenesis of atherosclerosis：a perspective for the 1990s［J］. Nature, 1993, 362(6423)：801-809.

［2］ 周启林，田国平.CD40CD40L与急性冠脉综合征的研究进展［J］.心脏杂志，2006，18（2）：239-241.

［3］ 袁铭，吴宗贵，黄佐，等.高血压并发症与患者血清可溶性CD40及CD40L水平的关系［J］.心脏杂志，2006，18（2）：231-233.

［4］ Viallard JF, Solanilla A, Gauthier B, et al．Increased soluble and platelet associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis ［J］．Blood, 2002, 99(7)：2612-2614.

［5］ Lutgens E,Cleutjens KB, Heeneman S, et al, Both early and delayed antiCD40L antibody treatment induces a stable plaque phenotype ［J］．Proc Natl Acad Sci USA, 2000,97(13)：7464-7469.

［6］ Phipps RP, Koumas L, Leung E, et al. The CD40CD40 ligand system: a potential therapeutic target in atherosclerosis［J］. Curr Opin Investig Drugs, 2001, 2(6):773-777.

［7］ Lee Y，Lee WH,Lee SC，et al．CD40L activation in circulation platelets in patients with acute coronary syndrome ［J］．Cardiology，1999，92(1)：11-16.

［8］ 陈颖敏，宋玮，刘建平，等. 通心络治疗急性冠脉综合征对血清sCD40L的影响［J］.上海第二医科大学学报,2005，25（7）:727-729.

［9］ Aukrust P，Mller F，Ueland T，et al.Enlanced levels of soluble and membrancebound CD40 ligand in patients with unstable anginepossible reflection of lymphocyte and platelet involvement in the pathogenesis of acute coronary syndrome ［J］. Circulation, 1999, 100(6)：614-620.

备注/Memo

备注/Memo:
收稿日期：2006-06-26.作者简介：陈颖敏，副主任医师，副教授 Email:chenyingmin@medmail.com.cn
更新日期/Last Update: