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|本期目录/Table of Contents|

乌司他丁对慢性心力衰竭患者炎症介质和T细胞亚群的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第3期
页码:
331-333，336
栏目:
临床研究
出版日期:
2008-05-20

文章信息/Info

Title:
Effect of ulinastatin on CRP and Tlymphocyte subsets in chronic heart failure patients
作者:
周素平; 杨成明; 石伟彬; 王旭开; 曾春雨
第三军医大学大坪医院野战外科研究所心内科，重庆 400042
Author(s):
ZHOU Suping;  YANG Chengming;  SHI Weibin;  WANG Xukai;  ZENG Chunyu
Department of Cardiology, Daping Hospital, Third Millitary Medical University, Chongqing, 400042, China
关键词:
乌司他丁; 心力衰竭; 慢性; T细胞亚群;  C反应蛋白; 脑钠尿肽
Keywords:
ulinastatin; chronic heart failure; Tlymphocyte subsets; Creactive protein; brain natriuretic peptide
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 探讨乌司他丁对慢性心力衰竭(chronic heart failure, CHF)患者T细胞亚群、炎症介质和心功能的影响。方法 将入选的63例CHF患者随机分为两组，一组（常规治疗组，n=32）仅接受常规的抗心力衰竭治疗,另一组（乌司他丁组，1×104 U/d，n=31）在常规治疗的基础上加用乌司他丁，观察治疗当天和第7天T细胞亚群、C反应蛋白（CRP）、脑钠尿肽（BNP）水平，心衰积分（HFS）、NYHA心功能分级及6min步行实验距离（m）的变化。 结果 住院后两组各有1例死亡，余61例患者完成了本实验。治疗7 d后，与入院时比较，乌司他丁组（n＝30）CHF患者CD4+ T细胞及CD4+/CD8+ T细胞的比例均显著升高（P<0.01），CRP及BNP的水平均明显降低（P<0.01）；HFS、NYHA心功能分级及6min步行实验距离（m）均有显著改善（P<0.01）。与常规治疗组（n=31）相比较，乌司他丁更能降低CRP的水平（P<0.05），并可上调CD4+ T细胞及CD4+/CD8+ T细胞的比例（P<0.05）。结论 在常规治疗心力衰竭的基础上加用乌司他丁，可以显著提高CHF患者的细胞免疫状况，减轻炎症反应。
Abstract:
AIM To investigate the therapeutic effect of ulinastatin on Tlymphocyte subsets, inflammatory mediator and cardiac function in patients with chronic heart failure (CHF). METHODS Sixtythree patients receiving conventional treatment were randomly allocated to either ulinastatin group (1×104 unit once a day, n=31) or conventional treatment group (n=32). Changes in the plasm Creactive protein (CRP), Tlymphocyte subsets, brain natriuretic peptide (BNP) level, conditions of the heart failure score (HFS), New York Heart Association function class, and 6minute walk test distance were observed in these CHF patients before and after the sevenday’s treatment. RESULTS Sixtyone patients completed the study, 1 patient died in ulinastatin group and 1 in conventional treatment group. In ulinastatin group (n=30), obvious increase of plasma levels of CD4+ T cell, and ratio of CD4+/CD8+ T cell (P<0.01), as well as significant decrease of expression of CRP and BNP were observed (P<0.01). HFS, NYHA function class and 6minute walk test distance improved (P<0.01). Ulinastatin upgraded of the levels of CD4+ T cell and ratio of CD4+/CD8+ T cell (P<0.05), and significantly decreased the concentration of CRP (P<0.05), compared with those in the conventional treatment group (n=31). CONCLUSION Conventional treatment, plus ulinastatin, significantly improves the immune condition and reduces the inflammatory reaction in CHF patients.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2007-04-25.通讯作者：杨成明,主任医师，主要从事动脉粥样硬化的基础与临床研究Email：yangchmin@163.com 作者简介:周素平，住院医师，硕士生Email：zhousp2005@163.com
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