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贝那普利对兔急性心肌梗死再灌注后内皮素-1及无复流的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第5期
页码:
521-524
栏目:
基础研究
出版日期:
2008-10-20

文章信息/Info

Title:
Effects of benazepril on endothelin1 and myocardial noreflow in a rabbit model of acute myocardial infarction and reperfusion
作者:
刘现亮1; 何国祥1; 赵希军2
1.第三军医大学西南医院心内科，重庆 400038； 2.滨州医学院附属医院心内科，山东 滨州 256603
Author(s):
LIU Xianliang1;  HE Guoxiang1;  ZHAO Xijun2
1.Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; 2.Department of Cardiology, Affiliated Hospital of Binzhou Medical College, Binzhou 256603, Shandong, China
关键词:
心肌梗死; 再灌注; 无复流现象; 贝那普利; 内皮素-1
Keywords:
myocardial infarction;  reperfusion;  noref1ow phenomenon;  benazepril;  edothelin-1
分类号:
Q556.3;R542.22
DOI:
-
文献标识码:
A
摘要:
目的 评价贝那普利对兔急性心肌梗死（AMI）再灌注后内皮素-1(endothelin1,ET-1)的影响及对无复流的防治作用。方法 新西兰大白兔24只随机分成对照组、贝那普利组［3 mg/(kg·d)］和假手术组，每组8只。将冠状动脉结扎60 min、松解120 min，制备AMI再灌注模型。梗死前、后和再灌注后，用导管法进行血液动力学测定。采用放射免疫测定法检测血浆及心肌组织中ET-1的水平，最终进行病理学分析。结果 与对照组相比，贝那普利组能明显降低兔AMI再灌注后血浆ET-1的水平(P<0.01)；而心肌组织中ET1的含量仅复流区显著降低(P<0.01)。与对照组相比，贝那普利可促进AMI后心功能的恢复，减少无复流的面积［对照组为75.3％结扎区(LA)，贝那普利组为35.9％LA，P<0.01］。结论 贝那普利能有效降低血浆及心肌组织中ET-1的水平，具有内皮保护作用；能有效地防治心肌梗死再灌注后无复流现象的发生。
Abstract:
AIM To evaluate the effects of benazepril on myocardial noreflow in a rabbit model of acute myocardial infarction and reperfusion. METHODS Twentyfour rabbits were divided randomly into 3 groups (8 each group), namely, control group, benazepril ［3 mg/(kg·d)］ group and sham operation group. The animals in the former two groups were subjected to a 60 minute coronary occlusion, followed by a 120 minute reperfusion. Data on haemodynamics were collected and the levels of ET1 in blood samples and myocardium were determined by radioimmunoassay (RIA). The areas of noreflow were evaluated with pathological means. RESULTS In benazepril group, the levels of plasma ET1 were significantly lower than those in the control group (P<001), whereas the level of ET1 in infarcted reflow myocardium was significantly lower than that in the control group (P<001). In the control group, the area of noreflow was 753％ of ligation area（LA）, whereas the area was significantly decreased to 359％ of LA in benazepril group (P<001). CONCLUSION Benazepril is effective in reducing ET1 in blood plasma and local myocardium and protecting endothelial cells. Benazepril also has some beneficial effects on preventing myocardial noreflow, improving left ventricular function and reducing infarcted area during acute myocardial infarction and reperfusion in rabbits.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2007-12-29.通讯作者:刘现亮,教授，主要从事冠心病介入治疗研究Email:xnklxl@163.com
更新日期/Last Update: