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曲美他嗪治疗缺血性心肌病心力衰竭的疗效及 血浆脑钠肽的变化和意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第5期
页码:
584-587
栏目:
临床研究
出版日期:
2008-10-20

文章信息/Info

Title:
Therapeutic effect of trimetazidine on patients with ischemic cardiomyopathy heart failure and significance of plasma level of brain natriuretic peptide
作者:
徐冉; 于波; 魏林; 芦文婷
哈尔滨市第一医院心内一科，黑龙江 哈尔滨 150010
Author(s):
XU Ran;  YU Bo;  WEI Lin;  LU Wenting
Department of Cardiology, First Municipal Hospital, Harbin 150010, Heilongjiang, China
关键词:
曲美他嗪; 心肌病; 缺血性; 心力衰竭; 脑钠尿肽
Keywords:
trimetazidine;  ischemic cardiomyopathy;  heart failure;  brain natriuretic peptide
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 观察曲美他嗪治疗缺血性心肌病心力衰竭的近期疗效（4周）及血浆脑钠尿肽（BNP）浓度的变化。方法 缺血性心肌病心力衰竭患者60例，随机分为常规治疗组（30例）和曲美他嗪组（30例），分别给予常规治疗和加用曲美他嗪治疗 4周，治疗前后分别用ELISA法检测血浆 BNP浓度，并与同期的超声结果对照，观察血浆BNP 与这些指标的关系。结果 治疗前两组患者血浆BNP水平无明显差异，但治疗后两组的血浆BNP水平均显著降低（均P<0.05），而曲美他嗪组降低更加明显；两组患者治疗后血浆BNP水平相比有显著性差异（P<0.05）。并且血浆BNP与左室射血分数（LVEF）和左室舒张末期内径（LVEDD）均显著负相关（r分别为-0.481、0.311；均P<0.05）。结论 血浆 BNP 作为曲美他嗪治疗缺血性心肌病心力衰竭的疗效随访指标，其敏感性优于超声心动图；血浆BNP 水平与 LVEF呈负相关、与 LVEDD呈正相关，可以作为心力衰竭的辅助诊断指标并对心力衰竭治疗监控有应用价值。
Abstract:
AIM To assess the 4week therapeutic effect of cardiomyopathy (TMZ) on patients with ischemic heart failure and the changes of plasma level of brain natriuretic peptide (BNP). METHODS Sixty patients with ischemic cardiomyopathy heart failure were randomly divided into routine treatment group (30) and TMZ treatment group (30) and the patients were treated for 4 weeks. After treatment, the changes of BNP were observed between the two groups and the correlation between BNP and ultrasound values was explored. RESULTS No statistic difference in the BNP level was found between the two groups before treatment. After the 4week treatment, the BNP level decreased in both groups, but the decrease was more marked in TMZ group, with significant difference between the two groups (P=0.042). The BNP level was significantly correlated to LVEF and LVEDD (r=0.481, 0.311; P<0.05). CONCLUSION TMZ has a positive effect on patients with ischemic cardiomyopathy heart failure, and the plasma BNP level, as followup index, has better sensitivity than echocardiography. BNP level is negatively correlated with LVEF and positively correlated with LVEDD.

参考文献/References

［1］ Dao Q, Krishnaswamy P, Kazanergra R, et al. Utility of Btypenatriuretic peptide in the diagnosis of congestive heart failure in anurgentcare setting［J］. J Am Coll Cardiol, 2001, 37(2):379-385.

［2］ 陈灏珠. 实用内科学［M］. 第10 版. 北京:人民卫生出版社,1997:1227-1229.

［3］ Feigenbaum H. Echocardiography［M］. 6th ed, Philadelphia, Pa: Lea and Febiger, 1999:366-368.

［4］ Sugihara K, Fujimoto S, Motomiya Y, et al. Usefulness of long axis Mmode echocardiographic measurements for optimum dialysis in patients on maintenance hemodialysis: comparison with changes in plasma levels of atrial natriuretic peptide and brain natriuretic peptide［J］. Clin Nephrol, 2001, 56(2):140-149.

［5］ Nishikimi T, Futoo Y, Tamano K, et al. Plasma brain natriuretic peptide levels in chronic hemodialysis patients:influence of coronary artery disease［J］. Am J Kidney Dis, 2001, 37(6):1201-1208.

［6］ 李德才,蒋涛,王庆旭,等. 脑钠肽在慢性心力衰竭中应用价值探讨［J］. 中国循环杂志, 2004, 19(2):91-93.

［7］ 周爱儒,查锡良. 生物化学 ［M］. 第5版. 北京: 人民卫生出版社， 2002:73.

［8］ 王联发,鲍正毅,邹宝明,等. 充血性心力衰竭患者血浆内皮素和一氧化氮的测定及其临床意义［J］. 心脏杂志， 2000， 12（5）：422.

［9］ 王联发,吴振西,尹欣,等. 心力衰竭患者血浆脑钠肽含量的变化［J］. 心脏杂志， 2006， 18（6）：625.

备注/Memo

备注/Memo:
收稿日期：2007-04-02. 作者简介：徐冉，医师，硕士Email：xuran@cumail.com.cn
更新日期/Last Update: