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急性冠脉综合征患者血浆BNP和MCP-1的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第5期
页码:
588-590
栏目:
临床研究
出版日期:
2008-10-20

文章信息/Info

Title:
Changes of peripheral blood levels of BNP and MCP1 in patients with acute coronary syndromes
作者:
胡艳; 吕安林; 温俊娜; 孟小雪; 宋延彬; 杜鹃鹃
第四军医大学西京医院心脏内科，陕西 西安 710032
Author(s):
HU Yan;  L Anlin;  WEN Junna;  MENG Xiaoxue;  SONG Yanbin;  DU Juanjuan
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China
关键词:
急性冠脉综合征; 心肌梗死; 急性; 心绞痛; 不稳定型; 脑纳尿肽; 单核细胞趋化蛋白-1
Keywords:
acute coronary syndromes;  acute myocardial infarction;  unstable angina;  Btype natriuretic peptide;  monocyte chemoattractant protein-1
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察急性冠脉综合征(ACS)患者外周血中脑纳尿肽(BNP)及单核细胞趋化蛋白-1(MCP-1)的变化,探讨BNP，MCP-1与ACS的关系。方法 住院ACS患者39例,采用ELISA测定血清BNP,MCP-1的水平。结果 ACS患者入院即刻血浆BNP和MCP1水平均显著高于对照组，分别为（560±25）ng/L vs (42±24)ng/L(P<0.01)和(152±19)ng/L vs (113±22)ng/L(P<0.01)。ACS组内不稳定心绞痛（UAP）亚组与急性心肌梗死（AMI）亚组比较,AMI亚组BNP水平高于UAP亚组［(557±24)ng/L vs (172±62)ng/L,P<0.01］,而MCP-1水平在AMI亚组和UAP亚组间无显著性差异［(153±19)ng/L vs (150±22)ng/L］。ACS组患者中BNP和MCP-1水平呈明显正相关(r=0625，P<0.01)。结论 ACS患者外周血BNP和MCP-1水平升高而且两者水平呈正相关。
Abstract:
AIM To investigate whether peripheral blood levels of Btype natriuretic peptide (BNP) and monocyte chemoattractant protein-1 (MCP-1) are affected in patients with acute coronary syndromes (ACS). METHODS Serum BNP and MCP-1 were measured in 38 patients with ACS by enzyme linked immunosorbent assay (ELISA). RESULTS ①The serum levels of BNP and MCP-1in ACS group were significantly higher than those in control groups (P<0.01, P<0.01). ②The serum level of BNP were significantly different between UA group and AMI group (P<0.01), but the serum level of MCP-1 was not significantly different between UA group and AMI group. ③There was an obvious correlation between BNP and MCP-1 in ACS group (r=0.625, P<0.01). CONCLUSION The serum levels of BNP and MCP-1 in patients with coronary artery disease increase and there is an obvious correlation between BNP and MCP1.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-01-03.通讯作者：吕安林,副主任医师,主要从事冠心病介入治疗的 研究Email:lvanlin@fmmu.edu.cn 作者简介：胡艳,硕士生Email:huyan1975@fmmu.edu.cn
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