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¡¶ÐÄÔàÔÓÖ¾¡·[ISSN:1009-7236/CN:61-1268/R]

ÆÚÊý:

2008ÄêµÚ6ÆÚ

Ò³Âë:

708-710

À¸Ä¿:

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³ö°æÈÕÆÚ:

2008-12-25

ÎÄÕÂÐÅÏ¢/Info

Title:

Elevated plasma levels of tissue factor activity, activated factor VII and factor VII antigen in Chinese Han patients with coronary artery disease

×÷Õß:

ºÎÎľê¹; 2; ºúÔ¥¹; 2; ÕÅСƽ¹; 2; ÎºÎÄÄþ¹; 2; ¹ùÌι; 2; ºé÷¹; 2; ËÎÉÆ¿¡¹; 2

1.»ªÖпƼ¼´óѧͬ¼ÃҽѧԺЭºÍҽԺѪҺ²¡Ñо¿Ëù,ºþ±± Î人 430022; 2.ºþ±±Ê¡ÉúÎï°ÐÏòÖÎÁÆÖصãʵÑéÊÒ£¬ºþ±± Î人 430022

Author(s):

HE Wenª²juan¹; 2;  HU Yu¹; 2;  ZHANG Xiaoª²ping¹; 2;  WEI Wenª²ning¹; 2;  GUO Tao¹; 2;  HONG Mei¹; 2;  SONG Shanª²jun¹; 2

1.Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; 2.Key Laboratory of Biological Targeted Therapy of Hubei Province, Wuhan 430022, Hubei, China

¹Ø¼ü´Ê:

¹Ú×´¶¯Âö¼²²¡; Îȶ¨ÐÍÐĽÊÍ´; ¼±ÐÔ¹Ú×´¶¯Âö×ÛºÏÕ÷

Keywords:

coronary disease;  stable angina;  acute coronary syndromes

·ÖÀàºÅ:

R541.4

DOI:

-

ÎÄÏ×±êʶÂë:

A

ÕªÒª:

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Abstract:

AIM To study the variation of tissue factor activity (aTF), activated factor VII (FVIIa) and factor VII antigen (FVII:Ag) levels in plasma of Chinese Han patients with coronary artery disease (CAD) and to explore their relationship with the number of coronary artery with stenosis. METHODS aTF was measured by chromogenic activity assay and FVIIa and FVII:Ag was measured by enzyme linked immunosorbent assay (ELISA). RESULTS Compared with those of controls, the plasma level of FVIIa (P<0.001), FVII:Ag (P<0.05) and aTF (P<0.05) were significantly higher in coronary artery disease group. The levels of aTF in patients with acute coronary syndromes (ACS) were found to be significantly higher than those in controls (P<0.01) or in stable angina pectoris (SAP) patients (P<0.05). But there was no difference in aTF between SAP patients and controls. There were no differences in FVIIa levels between ACS and SAP, which were both higher than those of controls. FVII:Ag levels in ACS patients were significantly higher than those in controls. For aTF, FVIIa and FVII:Ag, there were no differences between patients with various numbers of coronary artery with stenosis. CONCLUSION There is more or less activation of extrinsic coagulation pathway in patients with SAP or ACS, and elevated aTF may prognosticate onset of acute coronary events. FVIIa is perhaps an early marker of CAD. The number of coronary artery with stenosis can not reflect the degree of coagulation activation.

²Î¿¼ÎÄÏ×/References

£Û1£Ý Lisowski P, Malyszko J, Lisowska A, et al. Role of the hemostatic system in pathogenesis of atherosclerosis as the main etiology of coronary ischemia£ÛJ£Ý. Pol Merkur Lekarski, 2004, 16(95):465-467.

£Û2£Ý Steffel J, Luscher TF, Tanner FC. Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications£ÛJ£Ý. Circulation, 2006, 113(5):722-731.

£Û3£Ý Tilley R, Mackman N. Tissue factor in hemostasis and thrombosis£ÛJ£Ý. Semin Thromb Hemost, 2006, 32(1):5-10.

£Û4£Ý Mallat Z, Tedgui A. Current perspective on the role of apoptosis in atherothrombotic disease£ÛJ£Ý. Circ Res, 2001, 88(10):998-1003.

£Û5£Ý Corti R, Fuster V, Badimon JJ. Pathogenetic concepts of acute coronary syndromes£ÛJ£Ý. J Am Coll Cardiol, 2003, 41(4 Suppl S):7-14.

£Û6£Ý Meade TW, Ruddock V, Stirling Y, et al. Fibrinolytic activity, clotting factors, and longª²term incidence of ischaemic heart disease in the Northwick Park Heart Study£ÛJ£Ý. Lancet, 1993, 342(8879):1076-1079.

£Û7£Ý Heinrich J, Balleisen L, Schulte H, et al. Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM Study in healthy men£ÛJ£Ý. Arterioscler Thromb, 1994, 14(1):54-59.

£Û8£Ý Cooper JA, Miller GJ, Bauer KA, et al. Comparison of novel hemostatic factors and conventional risk factors for prediction of coronary heart disease£ÛJ£Ý. Circulation, 2000, 102(23):2816-2822.

£Û9£Ý ÁÎÃ÷·¼£¬¾°ÔÚƽ£¬¶¡Èã. ¶¯ÂöÖàÑùÓ²»¯ÑªË¨Ðγɼ²²¡µÄ·¢²¡»úÖƽøÕ¹£ÛJ£Ý. ¹ú¼Ê²¡Àí¿ÆѧÓëÁÙ´²ÔÓÖ¾£¬ 2006£¬ 26(2)£º106-109.

£Û10£ÝFisher SD, Zareba W, Moss AJ, et al. Effect of smoking on lipid and thrombogenic factors two months after acute myocardial infarction£ÛJ£Ý. Am J Cardiol, 2000, 86(8):813-818.

£Û11£ÝScarabin PY, Vissac AM, Kirzin JM, et al. Elevated plasma fibrinogen and increased fibrin turnover among healthy women who both smoke and use low-dose oral contraceptivesª²ª²a preliminary report£ÛJ£Ý. Thromb Haemost, 1999, 82(3):1112-1116.

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¸üÐÂÈÕÆÚ/Last Update: 2009-03-24