我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

超声心动图评价红斑狼疮患者右心功能损伤的可行性研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2008年第6期
页码:
734-736745
栏目:
临床研究
出版日期:
2008-12-25

文章信息/Info

Title:
Study on the feasibility of evaluating right ventricular function injury in SLE patients by echocardiography
作者:
王泓1; 曹铁生2; 杨斌1; 付宁华1;  孙晖1
1.南京军区南京总医院超声诊断科，江苏 南京 210002； 2.第四军医大学唐都医院超声诊断科，陕西 西安 710038
Author(s):
WANG Hong1;  CAO Tiesheng2;  YANG Bin1;  FU Ninghua1;  SUN Hui1
1.Department of Ultrasound Diagnostics, General Hospital, Nanjing Military Area Command, Nanjing 210002, Jiangsu, China; 2.Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China
关键词:
系统性红斑狼疮; 超声心动描记术; 评价; 心功能损伤
Keywords:
SLE;  echocardiography;  evaluation;  cardiac function injury
分类号:
R540.45
DOI:
-
文献标识码:
A
摘要:
目的 探讨超声心动图评价系统性红斑狼疮（SLE）患者右心功能损伤的可行性和敏感性。方法 将57例研究对象分为4组，即Ⅰ组（对照组）：超声心动图及查体均正常的体检者18例；Ⅱ组：左室收缩、舒张功能均正常的SLE患者18例；Ⅲ组：左室收缩功能正常、舒张功能减低的SLE患者13例；Ⅳ组：SLE并发肺动脉高压的患者8例。用脉冲多普勒采集三尖瓣口舒张期血流频谱，计算舒张早期和晚期速度的比值（TrE/A）；用组织多普勒采集三尖瓣环右室游离壁舒张早期峰值速度(Em)、舒张晚期峰值速度(Am)，并计算Em/Am值。根据公式(ICT＋IRT)/ET计算右心Tei指数，并测量右室射血分数（RVEF）。结果 Ⅰ、Ⅱ、Ⅲ、Ⅳ组的右心Tei指数依次增大，分别为0.25±0.062、0.29±0.087、0.41±0.15及0.53±0.21。Ⅳ组患者的各项心功能指标与其他组的差异均有显著性意义（P<0.05）。Ⅲ组患者的右心Tei指数、Em和Em/Ea的比值较Ⅰ组和Ⅱ组减低（P<0.05），而Ⅲ组患者的RVEF和TrE/A的比值与Ⅱ组和对照组的差异未见显著性意义。结论 右心Tei指数和三尖瓣环组织多普勒频谱能评估SLE患者右心功能的损害，较RVEF和TrE/A更为敏感。
Abstract:
AIM To evaluate the feasibility and sensibility of measuring right ventricular function injury in patients with systemic lupus erythematosus (SLE) by echocardiography. METHODS Eighteen healthy individuals (groupⅠ) and 39 SLE patients (groupⅡ, Ⅲ, Ⅳ) were included in the study. Group Ⅱwas SLE patients without left ventricular dysfunction, group Ⅲ was SLE patients with diastolic dysfunction of left ventricular and group Ⅳ was SLE patients with pulmonary hypertension. Tei index, ejection fraction of right ventricular (RVEF), spectrum of tricuspid (TrE/A) and the diastolic velocity of tricuspid annulus（Em, Em/Am）were obtained. RESULTS By the sequence from group Ⅰto group Ⅳ, Tei index gradually increased (0.25±0.062, 0.29±0.087, 0.41±0.15, 0.53±0.21). All the parameters of group Ⅳ were significantly different compared with those of the other three groups（P<0.05）. Tei index, Em and Em/Ea of group Ⅲ were significantly different with those of group Ⅰ and group Ⅱ（P<0.05）, while neither RVEF nor TrE/A in group Ⅲ was different from that of group Ⅰ and group Ⅱ. CONCLUSION Tei index and the diastolic velocity of tricuspid annulus obtained by tissue Doppler may be more sensitive than RVEF and TrE/A in evaluating right ventricular function injury in SLE patients.

参考文献/References

［1］ Doria A, Iaccarino L, SarziPuttini P, et al. Cardiac involvement in systemic lupus erythematosus［J］. Lupus, 2005, 14(9):683-686.

［2］ Miller D, Farah MG, Liner A, et al. The relation between quantitative right ventricular ejection fraction and indices of tricuspid annular motion and myocardial performance［J］. J Am Soc Echocardiogr, 2004, 17(5):443-447.

［3］ Tei C, Dujardin KS, Hodge DO, et al. Doppler echocardiographic index for assessment of global right ventricular function［J］. J Am Soc Echocardiogr, 1996, 9 (6):838-847.

［4］ Wallace DJ, Hahn BH. Dubois’ lupus erythematosus［C］. Philadelphia: Lippincott Williams & Wilkins, 2001: 645.

［5］ Misumi I, Harada E, Doi H, et al. Tei index evaluated by Mmode echocardiography in patients with dilated cardiomyopathy［J］. J Cardiol, 2002, 39(2): 85-91.

［6］ Koyama J, RaySequin PA, Falk RH, et al. Prognostic significance of ultrasound myocardial tissue characterization in patients with amyloidosis［J］. Circulation, 2002, 106(5):556-561.

［7］ Melek M, Esen O, Esen AM, et al. Tissue Doppler evaluation of tricuspid annulus for estimation of pulmonary artery pressure in patients with COPD［J］. Lung, 2006, 184 (3):121-131.

［8］ Watanabe M, Ono S, Tomomasa T, et al. Measurement of tricuspid annular diastolic velocities by Doppler tissue imaging to assess right ventricular function in patients with congenital heart disease［J］ . Pediatr Cardiol, 2003, 24(5):463-467.

［9］ Gin PL, Wang WC, Yang SH, et al. Right heart function in systemic lupus erythematosus: insights from myocardial Doppler tissue imaging［J］. J Am Soc Echocardiogr, 2006, 19(4):441-449.

备注/Memo

备注/Memo:
收稿日期：2007-12-04.通讯作者：曹铁生，主任医师，教授，主要从事心功能测定研究Email:caots@fmmu.edu.cn 作者简介：王泓，主治医师，博士Email：cathywh@126.com
更新日期/Last Update: 2009-03-24