克山病患者血浆B型钠尿肽水平的变化及其临床意义(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2008年第6期
- 页码:
- 746-748
- 栏目:
- 临床研究
- 出版日期:
- 2008-12-25
文章信息/Info
- Title:
- Changes of plasma Btype natriuretic peptide level in Keshan disease and their clinical significance
- Author(s):
- ZHANG Weijuan1; 2; NIU Xiaolin1; ZHU Jianhong1
- 1.Department of Cardiology, Second Hospital, Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China; 2.Xi’an Second Hospital, Xi’an 710003, Shaanxi, China
- 分类号:
- R542.3
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 评价不同类型克山病患者血浆B型钠尿肽(BNP)水平的变化及临床意义。方法 采用双抗夹心免疫荧光法测定25例慢型克山病患者、22例潜在型克山病患者、20例健康对照者血浆BNP浓度，并行超声心动图测定不同类型患者的心脏结构和功能。比较不同组浓度的差异以及各组水平间的相关性。结果 慢型克山病患者血浆BNP水平明显高于潜在型克山病患者及健康对照组（P<0.01），潜在型克山病患者血浆BNP水平明显高于健康对照组（P<0.01）；慢型克山病患者左室舒张末内径、左室射血分数、左室短轴缩短率与其他两组比较有显著性差异（P<0.01），而潜在型克山病患者与对健康照组比较无显著性差异；血浆BNP水平与左室舒张末内径呈正相关(r=0.76，P<0.01)，与左室射血分数和短轴缩短率均呈负相关(r=-0.50和r=-0.53，P<0.01)。结论 不同类型克山病患者血浆BNP水平均明显增高，并与心功能恶化程度呈正相关，BNP水平对克山病患者心功能不全早期诊断和预后评估具有重要意义。
- Abstract:
- AIM To evaluate the changes of plasma Btype natriuretic peptide level in different types of Keshan disease and their clinical significance. METHODS Sandwich doubleimmunofluorescence was employed to detect the levels of plasma Btype natriuretic peptide in 25 cases of chronic Keshan disease, 22 cases of potential Keshan disease, and 20 healthy controls. Echocardiography was performed to determine the cardiac structure and function of patients of different types. The levels of plasma Btype natriuretic peptide in different patients were compared and their correlation was studied. RESULTS The plasma BNP levels in chronic cases were significantly higher than those in potential cases and healthy control (P<0.01), and the plasma BNP levels in potential cases were significantly higher than those in healthy control group (P<0.01). Left ventricular enddiastolic diameter, left ventricular ejection fraction and left ventricular shortening fraction in chronic cases were significantly different from those in potential cases and healthy control (P<0.01), while no significant difference was found between potential cases and healthy control group. Plasma BNP levels and left ventricular enddiastolic diameter was positively correlated (r=0.51, P<0.01) and left ventricular ejection fraction and left ventricular shortening fraction was significantly negatively correlated (r=-0.38 and r=-0.44, P<0.05). CONCLUSION Plasma Btype natriuretic peptide levels significantly increase in different types of Keshan diseases and the increase in positively correlated to the deterioration of cardiac function. Btype natriuretic peptide levels are of great significance in early diagnosis and prognostic evaluation of cardiac function in patients with Keshan disease.
参考文献/References
［1］ Sudoh T, Kangawa K, Minamino N, et al. A new natriuretic peptide in porcine brain［J］. Nature, 1988, 332 (6159):78-81.
［2］ 夏德义，于维汉，倪国治. 克山病诊断标准［J］. 中国地方病学杂志， 1996， 15(6):367-376.
［3］ 赵雪燕,杨跃进,倪新海,等. 左心衰竭患者B型利钠肽与心功能指标的相关分析［J］. 中国循环杂志, 2006, 21(3):168-171.
［4］ Ancheta IB. Btype natriuretic peptide rapid assay. a diagnostic test for heart failure［J］. Dimens Crit Care Nurs, 2006, 25(4):149-154.
［5］ Zipes DP, Libby P, Borrow RO, et al. Braunwald’s heart disease: A textbook of cardiovascular medicine［M］. 7th ed. Philadephia: Elsevier Saunders, 2004:64-65,210-220.
［6］ McCullough PA, Omland T, Maisel AS. Btype Natriuretic Peptudes a diagnostic breakthrough for clinicians［J］. Rev Cardiovasc Med, 2003, 4(2):72- 80.
［7］ 胡大一，杨振华. B型钠尿肽的临床应用和最新进展［M］. 北京： 科学技术出版社， 2006:36-37.
［8］ 童明宏，左雪梅，张正银. B型钠尿肽对心力衰竭诊断价值的探讨［J］. 检验医学， 2007， 22(2):202-203.
备注/Memo
- 备注/Memo:
- 收稿日期：2008-06-30.通讯作者：牛小麟，教授，主任医师，主要从事心血管病研究Email:niuxl@mail.xjtu.edu.cn 作者简介：张维娟，主治医师，硕士生Email: zwjzyjzf@126.com
常用功能
统计/Statistics
- 摘要浏览/Viewed1267
- 全文下载/Downloads675
- 评论/Comments
