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|本期目录/Table of Contents|

核因子κB在心肌缺血/再灌注损伤中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第2期
页码:
271
栏目:
综述
出版日期:
2009-03-30

文章信息/Info

Title:
-
作者:
余伟 综述; 王伟 审校
汕头大学医学院第一附属医院心血管内科，广东 汕头 515041
Author(s):
-
关键词:
核因子κB; 心肌缺血/再灌注; 心肌炎症; 细胞凋亡; 氧化应激
Keywords:
-
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
核因子κB(NF-κB)是一种多效转录因子，在心肌缺血/再灌注损伤的病理生理过程中起着关键作用，参与了对心肌炎症反应、细胞凋亡和氧化应激过程的调控。
Abstract:
-

参考文献/References

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［2］ Zhang M, Xu YJ, Saini HK, et al. Pentoxifylline attenuates cardiac dysfunction and reduces TNF-α level in ischemic-reperfused heart［J］. Am J Physiol Heart Circ Physiol, 2005, 289(2):H832-H839.

［3］ Yeh CH, Chen TP, Wu YC, et al. Inhibition of NFκB activation with Curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia-reperfusion［J］. J Surg Res, 2005, 125(1):109-116.

［4］ Liakopoulos OJ, Schmitto JD, Kazmaier F, et al. Cardiopulmonary and systemic effects of methylprednisolone in patients undergoing cardiac surgery［J］. Ann Thorac Surg, 2007, 84(1):110-118.

［5］ Gu Q, Yang XP, Bonde P, et al. Inhibition of TNF-alpha reduces myocardial injury and proinflammatory pathways following ischemia-reperfusion in the dog［J］. J Cardiovasc Pharmacol, 2006, 48(6):320-328.

［6］ Shimamoto A, Chong AJ, Yada M, et al. Inhibition of Toll-like receptor 4 with Eritoran attenuates myocardial ischemia-reperfusion injury［J］. Circulation, 2006, 114(1 Suppl):I270-I274.

［7］ Stansfield WE, Moss NC, Willis MS, et al. Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury［J］. Ann Thorac Surg, 2007， 84(1):120-125.

［8］ Frantz S, Tillmanns J, Kuhlencordt PJ, et al. Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury［J］. Am J Pathol, 2007, 171(2):507-512.

［9］ Choi H, Kim SH, Chun YS, et al. In vivo hyperoxic preconditioning prevents myocardial infarction by expressing Bcl-2［J］. Exp Biol Med, 2006, 231(4):463-472.

［10］Kin H, Wang NP, Halkos ME, et al. Neutrophil depletion reduces myocardial apoptosis and attenuates NFkappaB activation/TNFalpha release after ischemia and reperfusion［J］. J Surg Res, 2006, 135(1):170-178.

［11］郭瑞威，杨丽霞，石燕昆，等. NF-κB在TNF-α致人脐静脉内皮细胞凋亡中的作用［J］. 心脏杂志, 2006, 18（2）:152-154.

［12］杨晓云，周宁，王琳，等. 辛伐他汀对NF-κB-DNA结合活性和表达的影响［J］. 心脏杂志， 2006, 14(4):369-372.

［13］Rui T, Kvietys PR. NFkappaB and AP-1 differentially contribute to the induction of MnSOD and eNOS during the development of oxidant tolerance［J］. FASEB J, 2005, 19(13):1908-1910.

［14］刘颖,吴伟康,陈晨,等. 核因子-κB在四逆汤预处理诱导大鼠心肌延迟预适应中的作用［J］. 中国中药杂志, 2005, 30(6):453-456.

［15］Li Q, Guo Y, Tan W, et al. Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-κB dependent pathway［J］. Circulation, 2007, 116(14):1577-1584.

备注/Memo

备注/Memo:
收稿日期：2008-1-11.基金项目：广东省自然科学基金重点项目资助（05008363） 通讯作者：王伟，主任医师，主要从事冠心病的诊治研究Email：stwangwei@126.com 作者简介：余伟，硕士生Email：yuwei10610048@126.com
更新日期/Last Update: 2009-04-16