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老年高血压病患者血清瘦素水平与颈动脉内膜中层厚度的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第4期
页码:
519-522
栏目:
临床研究
出版日期:
2009-06-25

文章信息/Info

Title:
Correlation between leptin and intima-media thickness of carotid artery in elderly hypertensive patients
作者:
贾灿萍1; 2; 单其俊1; 张旭东2; 孙恒芳2; 陈军2; 王晓玲2; 陈勇2
1.南京医科大学附属第一医院心内科，江苏 南京 210029；2.扬州大学附属医院老年科，江苏 扬州 225009
Author(s):
JIA Can-ping1; 2;  SHAN Qi-jun1;  ZHANG Xu-dong2;  SUN Heng-fang2;  CHEN Jun2;  WANG Xiao-ling2;  CHEN Yong2
1.Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China; 2.Department of Geriatrics, Affiliated Hospital, Yangzhou University, Yangzhou 225009, Jiangsu, China
关键词:
老年人; 瘦素; 高血压; 原发性; 颈动脉内膜中层厚度
Keywords:
elderly;  leptin;  hypertension;  primary;  intima-media thickness;  carotid wall
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨老年高血压病患者血清瘦素(Leptin)与颈动脉内膜中层厚度(IMT)的关系。方法 选取60岁以上老年高血压病患者111例为研究对象，进行血压、血糖、血脂、血清瘦素的测定并测定腰臀比(WHR)计算体质量指数（BMI），使用高分辨率超声检测双侧颈动脉IMT，把研究对象按IMT分为两组：IMT<1.0 mm(n=54)组和IMT≥1.0 mm(n=57)组，比较两组的差异，并进行相关性分析。结果 IMT≥1.0 mm组年龄、体质量、BMI、SBP、WHR、Leptin、TC、TG、HDL-C、LDL-C均显著高于IMT<1.0 mm组，leptin与IMT具有相关性(r=0.85,P<0.01)。结论 老年高血压病患者leptin与IMT明显相关。
Abstract:
AIM: To explore the relationship between leptin and intima-media thickness (IMT) of the carotid wall and to observe the effects of leptin on the development of arterial atherosclerosis in elderly hypertensive patients. METHODS: This study included 111 patients >60 years of age with hypertension (study group) and 43 healthy elderly patients (control group). Blood pressure, fasting serum leptin, fasting glucose and lipids were measured, and waist-to-hip ratio (WHR) and body mass index (BMI) were calculated in all subjects. IMT of carotid artery was quantified by high-resolution ultrasound imaging. Difference between groups was compared and the correlation was analyzed in the study group. RESULTS: A significant difference was found in systolic blood pressure, diastolic blood pressure, waist-to-hip ratio, leptin and IMT between groups (P<0.01). In the study group, leptin level was correlated with IMT level and IMT level was correlated positively with age, WHR and leptin (r=0.38, r=0.15, r=0.84, respectively)(all P<0.01). CONCLUSION: Hypertensive patients have higher levels of leptin and IMT than controls. Leptin level is significantly correlated with IMT in the study group.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-9-1.通讯作者：单其俊，主任医师，主要从事心脏电生理研究Email：qjshan@njmu.edu.cn 作者简介：贾灿萍，主治医师，硕士生Email：jiacp1996@yahoo.com.cn
更新日期/Last Update: 2009-06-15