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|本期目录/Table of Contents|

老年高血压病患者血尿酸水平及其他心血管相关因素(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第4期
页码:
517-518,522
栏目:
临床研究
出版日期:
2009-06-25

文章信息/Info

Title:
Analysis of serum uric acid and cardiovascular risk factors in elderly patients with essential hypertension
作者:
王云; 常志文
首都医科大学附属北京同仁医院干部医疗科，北京 100730
Author(s):
WANG Yun;  CHANG Zhi-wen
VIP Department, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
关键词:
高血压; 血尿酸; 血脂; 胰岛素抵抗
Keywords:
hypertension;  uric acid;  blood lipid;  insulin resistance
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 观察老年高血压病患者血尿酸,血脂,胰岛素抵抗指数和内生肌酐清除率等相关因素，探讨血尿酸在老年高血压病患者中的临床意义。方法 老年高血压病组78例（A组），中青年高血压病组57例（B组），老年健康对照组41例（C组）。测量体质量指数（BMI），腰围（WC），腰臀比（WHR），检测血尿酸（SUA），总胆固醇（TC），三酰甘油（TG），高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），空腹血糖(FBG)，空腹胰岛素水平（FIn），计算胰岛素抵抗指数（HOMA-IR），血肌酐(Scr)，计算内生肌酐清除率（Ccr）。结果 高尿酸血症发生率分别为A组：23%，B组：28%，C组：2%。A组与C组比较，A组BMI、WHR、SUA、TG、TC、SBP、DBP、FIn、HOMA-IR均明显升高，A组Ccr、HDL-C低于C组,具有统计学意义（P<0.05）； A组与B组比较，A组WHR、FIn、HOMA-IR、Ccr、DBP低于B组，具有统计学意义（P<0.05）。结论 高血压病患者高尿酸血症发生率明显升高，血尿酸可作为高血压病患者临床评估的重要指标之一。
Abstract:
AIM: To study serum uric acid (SUA), blood lipids, insulin resistance, and endogenous creatinine clearance in elderly hypertensive patients. METHODS: Serum uric acid and other clinical data were collected in 78 elderly hypertensive patients (group A), 57 middle-aged hypertensive patients (group B) and 41 elderly normal controls (group C). RESULTS: Hyperuricemia in groups A, B and C was 23, 28 and 2%, respectively. In group A, the BMI, waist-to-hip ratio (WHR), SUA, triglycerides, total cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), Fin and HOMA-IR were higher than in group C, but creatinine clearance (Ccr) and high-density lipoprotein cholesterol were lower than in group C (P<0.05). WHR, Fin, HOMA-IR, Ccr and DBP in group A were lower than in group B (P<0.05). CONCLUSION: The incidence of hyperuricemia is significantly increased in hypertensive patients. The serum uric acid is one of the important markers for clinical analysis in both elderly and middle-aged hypertensive patients.

参考文献/References

［1］ 张月安，武阳丰，赵连成.高血压与高尿酸血症［J］.山西医科大学学报，2001，32（2）: 133-134.

［2］ Franse LV, Pahor M, Di Bari M, et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program(SHEP)［J］. J Hypertens, 2000, 18(8): 1149-1154.

［3］ Taniguchi Y, Hayashi T, Tsumura K, et al. Serum uric acid and the risk for hypertension and type 2 diabetes in Japanese men: The Osaka health survey［J］. J Hypertens, 2001,19(7): 1209-1215.

［4］ Mazzali M， Hughes J， Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism［J］. Hypertension, 2001,38(5):1101-1106.

［5］ Conen D, Wietlisbach V, Bovet P, et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country［J］. BMC Public Health, 2004,4:9.

［6］ Watanabe S, Kang DH, Feng L, et al. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity［J］. Hypertension, 2002, 40(3):355-360.

［7］ Imazu M, Yamamoto H, Toyofuku M, et al. Hyperinsulinemia for the development of hypertension: data from the Hawaii-Los Angeles-Hiroshima Study［J］. Hypertens Res, 2001, 24(5):531-536.

［8］ Baker JF, Krishnan E, Chen L, et al. Serum uric acid and cardiovascular disease: recent development and where do they leave us?［J］. Am J Med, 2005, 118(8):816-826.

备注/Memo

备注/Memo:
收稿日期：2007-4-30.作者简介：王云，主治医师，硕士Email:tuanwy2004@yahoo.com.cn
更新日期/Last Update: 2009-06-15