我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

固醇调节元件结合蛋白-1c基因54G/C多态性与新疆维吾尔族冠心病的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第6期
页码:
844-847
栏目:
临床研究
出版日期:
2009-11-05

文章信息/Info

Title:
Association between genetic polymorphism of sterol regulatory element-binding protein-1c and Uygur patients with coronary heart disease in Xinjiang
作者:
谢翔; 马依彤; 杨毅宁; 付真彦 ; 王迎洪 ; 陈邦党;  刘芬
新疆医科大学第一附属医院心脏中心冠心病科，新疆 乌鲁木齐 830054
Author(s):
XIE Xiang;  MA Yi-tong;  YANG Yi-ning;  FU Zhen-yan;  WANG Ying-hong;  CHEN Bang-dang;  LIU Fen
Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang, China
关键词:
冠状动脉疾病; 固醇调节元件结合蛋白-1c; 基因多态性; 血糖; 三酰甘油
Keywords:
coronary heart disease;  sterol regulatory element-binding protein-1c;  gene polymorphism;  blood glucose;  triglyceride
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
目的: 探讨固醇调节元件结合蛋白-1c（SREBP-1c）基因18号外显子54G/C基因多态性与新疆地区维吾尔族人群冠心病的相关性。方法: 采用聚合酶链反应-限制性片段长度多态性方法，对260例冠心病患者和256例健康体检者SREBP-1c基因18号外显子54G/C位点进行分析，同时进行血糖及血脂水平检测。结果: SREBP-1c基因18号外显子54G/C在冠心病组和健康对照组中基因型频率分别为：CC型0.146和0.051，CG型0.346和0.387，GG型：0.508和0.563，两组CC基因型差异具有统计学意义（P<0.05），且冠心病组C等位基因频率高于对照组（P<0.01），而GC和GG基因型差异无统计学意义。不同基因型间血糖、血脂水平差异具有统计学意义（P<0.05）。结论: 固醇调节元件结合蛋白-1c基因CC基因型和等位基因C与新疆维吾尔族人群冠心病有关联，并可影响患者的血糖、三酰甘油代谢。
Abstract:
AIM: To investigate the association between the polymorphism of sterol regulatory element-binding protein-1c (SREBP-1c) and Uygur patients with coronary heart disease (CHD) in Xinjiang. METHODS: Two hundred and sixty patients with CHD and 256 healthy control subjects were detected by polymerase chain reaction-restriction fragment length polymorphism. Plasma lipid and glucose levels were also measured in all subjects. RESULTS: Genotype distribution of the control group and CHD group was in accordance with the Hardy-Weinberg equilibrium (χ2=3.45, 3.48, P<0.05). Frequencies of CC, GC and GG were 0.146, 0.346 and 0.508 in CHD group and 0.051, 0.387 and 0.563 in controls, respectively. There was a significant difference in frequencies of CC genotype and C allele but no difference in frequencies of GC and GG genotypes between controls and CHD cases. CONCLUSION: CC genotype and C allele of SREBP-1c may be a risk factor for CHD and has some significant influence on serum lipid and glucose levels in a Uygur nationality population in Xinjiang.

参考文献/References

［1］ Hlatky MA, Quertermous T, Boothroyd DB, et al. Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease［J］. Am Heart J， 2007， 154(6):1035-1042.

［2］ Marenberg ME, Risch N, Berkman LF. et al. Genetic susceptibility to death from coronary heart disease in a study of twins［J］. N Engl J Med， 1994, 330（15）：1041-1046.

［3］ Chen Q, Reis SE, Kammerer CM, et al. APOE polymorphism and angiographic coronary artery disease severity in the Women’s Ischemia Syndrome Evaluation(WISE) study［J］. Atherosclerosis, 2003,169 (1):159-167.

［4］ Li X, Du Y, Du Y, et al. Association of apolipoprotein E gene polymorphism with essential hypertension and its complications［J］. Clin Exp Med, 2003， 2（4）:175-179.

［5］ Meisel C, Afshar-Kharghan G, Casorbi I, et al. Role of Kozak sequence polymorphism of platelet glycoprotein Iba as a risk factor for coronary artery disease and catheter interventions［J］. J Am Coll Cardiol, 2001, 38（10）:1023-1027.

［6］ 徐耕，金国栋，傅国胜，等. 凝血因子Ⅴ和Ⅶ基因多态性与冠心病的初步研究［J］. 中华医学遗传学杂志， 2003， 20（1）：39-42.

［7］ Wang H, Kour IG, Wollheim CB. ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity［J］. J Cell Sci, 2005, 118(Pt17):3905-3915.

［8］ Mcpherson R, Gauthier A. Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid sythesis［J］. Biochem Cell Biol, 2004, 82(2):201-211.

［9］ Eberle D, Clement K, Meyre D, et al. SREBF-1 gene polymorphism are associated with obesity and type 2 diabetes in French obese and diabetic cohorts［J］. Diabetes, 2004, 53(8):2153-2157.

［10］徐献群，周新，郑芳，等. 固醇调节元件结合蛋白-1c基因多态性与冠状动脉粥样硬化的关系［J］.微循环学杂志， 2007， 17(4)：59-61.

［11］卡丽比努尔·雅克甫，古丽扎尔·买买提明，何秉贤. 新疆墨玉县10,906例维吾尔族住院病人心血管病种10 年回顾［J］. 中国病案， 2007， 8 （10）：47-48.

［12］张丽萍，汪师贞，赵学信,等. 内皮型一氧化氮合酶基因G894T多态性与新疆维吾尔族原发性高血压的关联研究［J］. 中华心血管病杂志， 2006， 34（5）：403-406.

［13］Hlatky MA, Quertermous T, Boothroyd DB, et al. Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease［J］. Am Heart J, 2007， 154(6):1035-1042.

［14］Foufelle F, Ferre P. Regulation of carbohydrate metabolism by insulin: role of transcription factor SREBP-c in the hepatic transcriptional effects of the hormone［J］. J Soc Biol， 2001， 195(3)：243-248.

备注/Memo

备注/Memo:
收稿日期：2008-2-11.基金项目：新疆自治区重大科技专项课题资助（XJEDU 2005 G03） 通讯作者：马依彤，主任医师，教授，主要从事冠心病介入治疗及基础研究Email:myt-xj@163.com 作者简介：谢翔，主治医师，硕士生Email:xiangxie999@163.com
更新日期/Last Update: 2009-09-30