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|本期目录/Table of Contents|

新型共信号分子B7-H3表达水平与急性心肌梗死预后的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第1期
页码:
81-83
栏目:
临床研究
出版日期:
2010-01-04

文章信息/Info

Title:
Clinical investigation of serum-soluble B7-H3 in patients with acute myocardial infarction
作者:
张小民1; 赵楚敏1; 宋月霞1; 刘春荣1; 张光波2
1.唐山市人民医院心内科，河北 唐山 063001；2.苏州大学 附属第一医院临床免疫学重点实验室，江苏 苏州 215006
Author(s):
ZHANG Xiao-min1;  ZHAO Chu-min1;  SONG Yue-xia1;  LIU Chun-rong1;  ZHANG Guang-bo2
1.Department of Cardiology, People’s Hospital of Tangshan, Tangshan 063001, Hebei, China; 2.Clinical Immunology Laboratory of Jiangsu Province, First Affiliated Hospital, Suzhou University, Suzhou 215006, Jiangsu, China
关键词:
心肌梗死; 急性; 免疫炎症; 共信号分子; 表达
Keywords:
myocardial infarction;  acute;  immune and inflammatory;  B7-H3 expression
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨新型共信号分子B7-H3在急性心肌梗死（AMI）的表达情况，进一步探讨其与AMI预后的关系。方法: 运用ELISA及免疫组化技术观察B7-H3在116例AMI患者的表达情况，同时把AMI患者B7-H3的检验结果与预后的关系进行分析，判断其是否有相关性。结果: AMI患者1年内心血管事件发生者比未发生者血浆B7-H3水平明显升高（P<0.05）。结论: 血浆B7-H3升高的幅度与AMI后患者心血管事件的发生有一定关系。
Abstract:
AIM: To explore a new type of signaling molecule (B7-H3) in acute myocardial infarction (AMI) expression and to further investigate its relationship with the prognosis of AMI. METHODS: ELISA and immunohistochemistry were used to observe the new technology of signaling molecules B7-H3 in 116 AMI patients. Analysis was conducted on the test results of B7-H3 in AMI patients and the prognosis to determine their relationship. RESULTS: Compared with those in control group, serum levels of soluble B7-H3 protein in AMI patients were higher. In AMI patients with cardiovascular events within 1 year, plasma levels of B7-H3 were significantly higher, compared with AMI patients who had no cardiovascular events (P<0.05). CONCLUSION: Plasma B7-H3 is significantly higher in patients with AMI and the increase is, to some extent, related to the occurrence of cardiovascular events.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-8-4.通讯作者：张小民，主任医师，主要从事冠心病及动脉粥样硬化的研究Email:zxm196175@sina.com.cn
更新日期/Last Update: 2010-01-05