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|本期目录/Table of Contents|

心肌肌球蛋白重链与心室重构

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
258-260，263
栏目:
综述
出版日期:
2010-03-04

文章信息/Info

Title:
-
作者:
周洪武 综述
上海中医药大学2006级硕士研究生，上海 200021
Author(s):
-
关键词:
心肌肌球蛋白重链; 心室重构; 心力衰竭
Keywords:
-
分类号:
Q593.3
DOI:
-
文献标识码:
A
摘要:
心室重构是心力衰竭发生、发展过程中的重要环节，胚胎基因再表达是衰竭心脏心室重构的重要分子标志之一。哺乳动物的心肌中含有两种肌球蛋白重链（MHC）基因，即α、β亚型。MHC的V1（由αMHC构成）比MHC的V3（由βMHC构成）有较大的ATP酶活性和收缩速率。心力衰竭时，αMHC向βMHC转换。
Abstract:
-

参考文献/References

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［3］ Carniel E, Taylor MR, Sinagra G, et al . α-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy［J］. Circulation, 2005, 112(1):54-59.

［4］ Schultz RL, Swallow JG, Waters RP, et al. Effects of excessive long-term exercise on cardiac function and myocyte remodeling in hypertensive heart failure rats［J］. Hypertension, 2007, 50(2):410-416.

［5］ Konhilas JP, Watson PA, Maass A, et al. Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy［J］. Circ Res, 2006, 98(4)：540-548.

［6］ Rundell VL, Manaves V, Martin AF, et al. Impact of β-myosin heavy chain isoform expression on cross-bridge cycling kinetics ［J］. Am J Physiol Heart Circ Physiol, 2005, 288(2):H896-H903.

［7］ Herron TJ, Vandenboom R, Fomicheva E, et al. Calcium-independent negative inotropy by β-myosin heavy chain gene transfer in cardiac myocytes［J］. Circ Res, 2007, 100(8)：1182-1190.

［8］ Hoyer K, Krenz M, Robbins J, et al. Shifts in the myosin heavy chain isozymes in the mouse heart result in increased energy efficiency［J］. J Mol Cell Cardiol, 2007, 42(1):214-221.

［9］ Okere IC, Young ME, McElfresh TA, et al. Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension［J］. Hypertension, 2006, 48(6):1116-1123.

［10］Tao ZW, Huang YW, Xia Q, et al. Combined effects of ramipril and angiotensin II recptor blocker TCV116 on rat congestive heart failure after myocardial infarction［J］. Chin Med J, 2005, 118（2）：146-154.

［11］Patiyal SN, Sharma S. Chronic oral administration of beta-adrenoceptor agonist clenbuterol affects myosin heavy chain (MHC) expression in adult mouse heart［J］. Physiol Res, 2007, 56(3):275-283.

［12］Davis FJ, Pillai JB, Gupta M, et al. Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of α-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility［J］. Am J Physiol Heart Circ Physiol, 2005, 288(3):H1477-H1490.

备注/Memo

备注/Memo:
收稿日期：2008-12-22.作者简介：周洪武，硕士生Email：555zhou@sohu.com
更新日期/Last Update: 2010-03-05