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|本期目录/Table of Contents|

先天性心脏病患者远期并发心律失常的分子遗传学机制

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第2期
页码:
282-284,288
栏目:
综述
出版日期:
2010-03-04

文章信息/Info

Title:
-
作者:
范粉灵马爱群张玉顺马东江和旭梅万红梅
西安交通大学医学院第一附属医院先心及周围血管病中心,陕西 西安 710061
Author(s):
-
关键词:
先天性心脏病心律失常分子遗传学机制
Keywords:
-
分类号:
R541.1
DOI:
-
文献标识码:
A
摘要:
先天性心脏病(congenital heart disease,CHD)是一种最常见的出生缺陷,为自然流产和死胎最常见的原因之一。最近研究提示,在心脏发育中,NKx2.5,SCN5A等基因的异常,不但会导致人类CHD的发生,而且可能会影响成年后心脏的正常功能。CHD患者远期并发的心脏疾患可能与这些基因的异常有关。
Abstract:
-

参考文献/References

[1] Jenkins KJ, Correa A, Feinstein JA, et al. Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics[J]. Circulation, 2007, 115(23):2995-3014.

[2] Zeppenfeld K, Schalij MJ, Bartelings MM, et al. Catheter ablation of ventricular tachycardia after repair of congenital heart disease: electroanatomic identification of the critical right ventricular isthmus[J]. Circulation, 2007, 116(20):2241-2252.

[3] Rivera-Rodríguez L, Cline B. Incidence and clinical features of arrhythmias after surgical treatment of congenital heart disease[J]. Arch Cardiol Mex, 2007, 77 (Suppl 2):S2-51-S2-53.

[4] Pierpont ME, Basson CT, Benson DW Jr, et al. Genetic basis for congenital heart defects: Current knowledge: A scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: Endorsed by the American Academy of Pediatrics[J].Circulation, 2007, 115(23):3015-3038.

[5] Oyamada M, Oyamada Y, Takanatsu T. Regulation of connexin expression[J]. Biochimi Biophysi Acta, 2005, 1719(1-2):6-23.

[6] Viswanathan PC, Balser JR. Molecular basis of isolated cardiac conduction disease[J]. Handb Exp Pharmacol, 2006, (171):331-347.

[7] 张晶,朱鲜阳. NKx2.5基因与先天性心脏病的关系[J]. 心脏杂志, 2008, 20(1):111-113.

[8] Gong LG, Qiu GR, Xin N, et al. Cloning of TBX5, a key gene during heart formation and its expression in rat embryonic heart [J]. Yi Chuan Xue Bao, 2006, 33(3):199-205.

[9] 莫小阳,马文丽,张亚莉,等. 先天性心脏病有关的风疹病毒Oligo探针与功能基因芯片的设计[J]. 心脏杂志, 2006, 18(6):632-635.

备注/Memo

备注/Memo:
收稿日期:2008-5-8.基金项目:陕西省科技攻关项目资助(2007K13-03) 通讯作者:马爱群,教授,主要从事心血管疾病研究Email:Maaiqun@medmail.com.cn 作者简介:范粉灵,讲师,博士生Email:finny1115@sina.com
更新日期/Last Update: 2010-03-05