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|本期目录/Table of Contents|

血清髓过氧化物酶水平与慢性心力衰竭有关

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第3期
页码:
415-416,420
栏目:
临床研究
出版日期:
2010-04-06

文章信息/Info

Title:
Clinical study of plasma myeloperoxidase levels and chronic heart failure
作者:
王宇楠; 毕亚艳; 王越红; 吴磊
哈尔滨医科大学附属一院心内六科，黑龙江 哈尔滨 150001
Author(s):
WANG Yu-nan;  BI Ya-yan;  WANG Yue-hong;  WU Lei
Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China
关键词:
髓过氧化物酶; 心力衰竭; 关联性
Keywords:
MPO;  heart failure;  relationship
分类号:
R541.61；R318.11
DOI:
-
文献标识码:
A
摘要:
目的: 研究髓过氧化物酶（MPO）与慢性心力衰竭（CHF）及CHF严重程度的关系。方法: 选取连续入院的74名NYHAⅡ～Ⅳ级的CHF患者及55名作为对照的非CHF患者，采用ELISA法测量其血清MPO浓度。采用多元线性回归分析血清MPO水平与CHF及其严重程度的关系。结果: 在调整了混杂因素后，CHF患者血清MPO水平显著高于对照组［（16±5）μg/L vs. (9±4)μg/L,P<0.01］，并随着NYHA分级的增加而升高（r=0.34,P<0.01）。结论: 血清MPO浓度在CHF患者中升高，并且与CHF严重程度相关。
Abstract:
AIM: To explore the relationship between plasma myeloperoxidase (MPO) levels and the severity of chronic heart failure (CHF). METHODS: Plasma MPO concentrations were measured by ELISA in 74 consecutive patients with New York Heart Association Class II-IV chronic systolic heart failure (HF) and 55 controls (no history of heart failure). The relationship between the plasma MPO levels and CHF was analyzed by multiple linear regression. RESULTS: After adjusting for confounders, plasma MPO levels in patients with chronic systolic HF were significantly elevated compared with those in the control group ［(16±5) vs.(9±4) μg/L, P<0.01］. Furthermore, plasma MPO levels elevated with the increase of the New York Heart Association Class (Spearma’s r=0.34, P<0.01). CONCLUSION: Plasma MPO levels are elevated in patients with chronic systolic HF and the elevation is associated with the severity of HF.

参考文献/References

［1］ Tang WH, Brennan ML, Philip K, et al. Plasma myeloperoxidase levels in patients with chronic heart failure［J］. Am J Cardiol, 2006, 98(6):796-799.

［2］Michowitz Y, Kisil S, Guzner-Gur H, et al. Usefulness of serum myeloperoxidase in prediction of mortality in patients with severe heart failure［J］. Isr Med Assoc J, 2008, 10(12):884-888.

［3］ Zhang C, Patel R, Eiserich JP, et al. Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid［J］. Am J Physiol, 2001, 281(4):H1469-H1475.

［4］ Katz SD, Hryniewicz K, Hriljac I, et al. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure［J］.Circulation, 2005, 111(3):310-314.

［5］ Zhu XY, Daghini E, Chade AR, et al. Role of oxidative stress in remodeling of the myocardial microcirculation in hypertension［J］. Arterioscler Thromb Vasc Biol, 2006, 26(8):1746-1752.

备注/Memo

备注/Memo:
收稿日期：2009-07-19.通讯作者：毕亚艳，副主任医师，主要从事心衰及房颤的诊断 与治疗研究Email：biyayan@163.com 作者简介：王宇楠，住院医师，硕士 wangyunan2008@yahoo.com.cn
更新日期/Last Update: 2010-04-09