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|本期目录/Table of Contents|

脉压与冠状动脉病变程度的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第3期
页码:
417-420
栏目:
临床研究
出版日期:
2010-04-06

文章信息/Info

Title:
Relationship between pulse pressure and extent of coronary artery disease
作者:
王归真1; 娄莉1; 王东琦2; 李云萍1; 崔长琮2
1.西安市第四医院心内科,陕西 西安 710004;2.西安交通大学第一医院心内科,陕西 西安 710064
Author(s):
WANG Gui-zhen;  LOU Li;  WANG Dong-qi;  LI Yun-ping;  CUI Chang-cong
Department of Cardiology, Fourth Hospital of Xi’an, Xi’an 710004, Shaanxi, China
关键词:
冠状动脉病变; 脉压; 收缩压; 舒张压; 年龄
Keywords:
coronary artery disease;  pulse pressure;  systolic pressure;  diastolic pressure;  age
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的: 探讨脉压(PP)与冠状动脉病变(CAD)程度的关系。方法: 对515例因胸痛而住院的患者进行冠状动脉造影，分析确诊的338例冠心病患者和177例非冠心病患者的年龄、收缩压(SBP)、舒张压(DBP)、平均压(MAP)、PP和CAD支数等临床特点。结果: ①与非冠心病患者相比，冠心病患者的年龄、SBP、MAP和PP均增加，男性和并发高血压病(EH)比例均增加(P<0.05，P<0.01)。②随着CAD支数的逐渐增加，年龄增加的变化，以及男性和并发EH比例增加的变化均有高度显著性差异(均P<0.01)；SBP和PP增加的变化有显著性差异(均P<0.05)。与非冠心病患者相比，1支病变、2支病变和3支病变患者的年龄、SBP、MAP和PP增加，男性和并发EH比例均增加(P<0.05，P<0.01)；3支病变与1支病变相比年龄增加(P<0.05)。③随着PP的逐渐增加，冠心病患者的年龄、SBP、MAP和CAD支数均逐渐增加，并发EH比例亦逐渐增加，均有高度显著性差异(均P<0.01)；男性比例呈减低改变，有高度显著性差异(P<0.01)。结论: PP水平与CAD有显著的关系：PP增大者，其CAD支数增加；而PP的增加与年龄和并发EH的增加有关。
Abstract:
AIM: To probe into the relationship between pulse pressure (PP) and extent of coronary artery disease (CAD). METHODS: Coronary artery angiography was performed in 515 hospitalized patients with chest pain. Comparison was conducted according to age, systolic pressure (SBP), diastolic pressure (DBP), mean aortic pressure (MAP), PP and extent of CAD among the 338 confirmed CAD cases and the 177 non-CAD cases. The extent of CAD was evaluated by the numbers of involved coronary arteries. RESULTS: Compared with those in non-CAD cases, a significant increase was observed in age, SBP, MAP and PP in CAD cases. CAD and complication of essential hypertension (EH) significantly increased in males in accordance with the higher number of involved coronary arteries (all P<0.05, P<0.01). With the increase of PP level, there was a significant increase in age, SBP, MAP, extent of CAD and complication with EH, but a decrease in the incidence of CAD in males (all P<0.05, P<0.01). CONCLUSION: PP is closely related with CAD. The number of involved coronary arteries increases with PP. The increase of PP is associated with higher age and EH.

参考文献/References

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[7]Tropea BI, Schwarzacher SP, Chang A, et al. Reduction of aortic wall motion inhibits hypertension- mediated experimental atherosclerosis［J］. Arterioscler Thromb Vasc Biol, 2000, 20(9):2127-2133.

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备注/Memo

备注/Memo:
收稿日期：2008-09-16.基金项目：西安市科技攻关计划（GG04110） 通讯作者：王归真，主任医师，主要从事临床心血管病研究 Email:wangguizhen4451@yahoo.com.cn
更新日期/Last Update: 2010-04-09