文章摘要

文章信息/Info

Title:: -

作者:: 叶明翔¹; 裴建明²; 第四军医大学：1.口腔医学系，2.生理学教研室，陕西西安 710032

Author(s):: -

关键词:: 他汀类药物; 血脂调节; 药物副作用; 合理用药

Keywords:: -

分类号:: R972.6

DOI:: -

文献标识码:: A

摘要:: 他汀类药物是羟甲基戊二酰辅酶还原酶的抑制剂，由于具有血脂调节作用，它被广泛用于高血脂患者心脑血管事件的一级预防和二级预防。此外，他汀类药物也被用于肺部疾病和肿瘤的辅助治疗中。但是近期研究表明长期使用他汀类药物会发生严重的副作用。本文结合这方面的最新研究对他汀类药物的有益作用和有害作用作一综述，并针对其严重的副作用提出一些预防措施，推荐了他汀与其他药物的配伍方案以期提高该药物使用的安全性。

Abstract:: -

参考文献/References

［1］桑震池，陈书艳. 他汀类药物、烟酸、抗氧化剂对降脂和冠状动脉粥样硬化的作用［J］. 心脏杂志, 2008, 20(4):487-490.

［2］ Khush K, Waters D, Bittner V, et al. Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets study［J］. Circulation, 2007, 115(5):576-583.

［3］Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein［J］. N Engl J Med, 2008, 359(21):2195-2207.

［4］ Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack［J］. N Engl J Med, 2006, 355(6):549-559.

［5］ Sillberg VA, Wells GA, Perry JJ. Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis ［J］. Stroke, 2008, 39(9): 2622-2626.

［6］ Johnson-Anuna LN, Eckert GP, Franke C, et al. Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein［J］. J Neurochem, 2007, 101(1):77-86.

［7］Syseth V, Brekke PH, Smith P, et al. Statin use is associated with reduced mortality in COPD［J］. Eur Respir J, 2007, 29(2):279-283.

［8］Lee JH, Lee DS, Kim EK, et al. Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs［J］. Am J Respir Crit Care Med, 2005, 172(8):987-993.

［9］ Lee TM, Lin MS, Chang NC. Usefulness of C-reactive protein and interleukin-6 as predictors of outcomes in patients with chronic obstructive pulmonary disease receiving pravastatin［J］. Am J Cardiol, 2008, 101(4):530-535.

［10］Mortensen EM, Restrepo MI, Anzueto A, et al. The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia［J］. Respir Res, 2005, 6:82.

[11]Frost FJ, Petersen H, Tollestrup K, et al. Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins［J］. Chest, 2007, 131(4):1006-1012.

[12]Demierre MF, Higgins PD, Gruber SB, et al. Statins and cancer prevention［J］. Nat Rev Cancer, 2005, 5(12):930-942.

[13]Kotamraju S,Willliams CL, Kalyanaraman B. Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways［J］. Cancer Res, 2007, 67(15):7386-7394.

[14]Khanzada UK, Pardo OE, Meier C, et al. Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signaling［J］. Oncogene, 2006, 25(6):877-887.

[15]Sivaprasad U, AbbasT, Dutta A. Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells［J］. Mol Cancer Ther, 2006, 5(9):2310-2316.

[16]Woodard J, Sassano A, Hay N, et al. Statin-dependent suppression of the Akt/mammalian target of rapamycin cascade and programmed cell death 4 up-regulation in renal cell carcinoma［J］. Clin Cancer Res, 2008, 14(14):4640-4649.

[17]Minichsdorfer C, Hohenegger M. Autocrine amplification loop in statin-induced apoptosis of human melanoma cells［J］. Br J Pharmacol, 2009, 157(7):1278-1290.

[18]Tandra S, Vuppalanchi. Use of statins in patients with liver disease［J］. Curr Treat Options Cardiovasc Med, 2009, 11(4):272-278.

[19]Beltowski J, Wójcicka G, Jamroz-wisniewska A. Adverse effects of statins-mechanisms and consequences［J］. Curr Drug Saf, 2009, 4(3):209-228.

[20]Smiley WH, Khan BV, Sperling LS. Management of the statin-intolerant patient［J］. Curr Treat Options Cardiovasc Med, 2009, 11(4):263-271.

我们的网站为什么显示成这样？

他汀类药物的功与过：降血脂药的使用新理念

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

文章信息/Info

参考文献/References

备注/Memo

常用功能

导航/Navigate

工具/Tools

统计/Statistics