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|本期目录/Table of Contents|

趋化因子CCL21、CCL19与急性冠状动脉综合征的相关性研究

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2010年第5期
页码:
699-701,704
栏目:
临床研究
出版日期:
2010-06-22

文章信息/Info

Title:
Relationship between chemokines CCL19 and CCL21 and acute coronary syndrom
作者:
刘鸿涛1; 2; 曾秋棠1; 毛小波1; 易桂文1; 李付兵1; 郑劲松1; 吉庆伟1
1.华中科技大学同济医学院附属协和医院心血管内科，湖北 武汉 430022；2.湖北省荆门市第二人民医院心血管内科，湖北 荆门 448000
Author(s):
LIU Hong-tao1; 2;  ZENG Qiu-tang1;  MAO Xiao-bo1;  YI Gui-wen1;  LI Fu-bing1;  ZHENG Jin-song1;  Ji Qing-wei1
1.Department of Cardiovascular Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China; 2.Department of Cardiovascular Medicine, Second Hospital of Jingmen City, Jingmen 448000, Hubei, C
关键词:
急性冠状动脉综合症; 急性ST段抬高心肌梗死; 非ST段抬高心肌梗死; 不稳定型心绞痛; 趋化因子; CCL21;  CCL19
Keywords:
acute coronary syndrome;  ST-segment elevation myocardial infarction;  non-ST-segment elevation myocardial infarction;  unstable angina;  chemokines;  CC21;  CC19
分类号:
R543.3
DOI:
-
文献标识码:
A
摘要:
目的：通过研究急性冠脉综合征(ACS)患者血清趋化因子CCL21、CC19的变化，探讨其与冠状动脉病变的相关性。方法: 选取102例ACS患者，其中急性ST段抬高的心肌梗死(STEMI)患者33例，非ST段抬高的心肌梗死（NSTEMI）37例，不稳定型心绞痛(UA)患者32例，稳定型心绞痛患者36例，非心源性胸痛并经冠状动脉造影排除冠心病的患者为对照组30例，采用酶联免疫法法测定CCL21、CCL19水平，所有ACS患者进行冠状动脉造影用目测法和Gensini评分对冠脉血管进行损害程度进行评价，来探讨CCL21、CCL19与冠状动脉狭窄范围及程度的关系。结果: ACS组CCL21及CCL19水平明显高于稳定型心绞痛组和对照组，分别为［(149.33±26.24)ng/L vs.(111.45±24．31)ng/L vs.(108.38±22.28)ng/L，P<0.01］，［(77.45±16.27)ng/L vs.(54.74±19.44) vs.(57.38±21.28)ng/L，P<0.01］。 ACS中STEMI、NSTEMI、UA组内血清CCL21、CCL19水平在组内差异无统计学意义［CCL21：(155.39±21.56)ng/L vs.(154．38±20．74)ng/L vs.(157.39±24.33)ng/L，P>0.05;CCL19:(75.34±15.34)ng/L vs.(77.25±16.21)ng/L vs.(74.23±24.19)ng/L，P>0.05］，冠状动脉狭窄程度及Gensini评分法积分在ACS组内STEMI组、NSTEMI组、UA组比较差异无统计学意义，三组内冠状动脉狭窄程度与外周血CCL21、CCL19水平无明显相关性。结论: 外周血CCL21、CCL19水平与急性冠脉综合症血管病变有关，在斑块不稳定中可能扮演着重要的角色。
Abstract:
AIM: To explore the relationship between chemokines CCL19 and CCL21 and the degree of stenosis of coronary artery in patients with acute coronary syndrome (ACS). METHODS: One hundred and two patients with acute ACS were included in the study. Included were 33 cases with ST-segment elevation myocardial infarction (STEMI), 37 cases with non ST-segment elevation myocardial infarction (NSTEMI), 32 cases with unstable angina, and 36 cases with stable angina (SA). Recruited as controls were 30 patients with chest pain but no ischemic changes in ECG and no coronary heart disease confirmed by coronary angiography. The levels of chemokines CCL19 and CCL21 were measured by ELISA and the severity of coronary artery disease was measured by Gensini scoring system. RESULTS: Serum levels of chemokines CCL19 and CCL21 in patients with ACS were significantly higher than those in control group ［CCL21: (149.33±26.24) ng/L vs.(111.45±22.28) ng/L vs.(108.38±22.28) ng/L, P<0.01］ and ［CCL19: (77.45±16.27) ng/L vs.(54.74±19.44) ng/L vs.(57.38±21.28) ng/L, P<0.01］. No significant difference was observed in Gensini scores among the three groups of ACS patients. The levels of chemokines CCL19 and CCL21 in peripheral blood were not correlated with coronary artery lesions in ACS. CONCLUSION: Levels of CCL19 and CCL21 may reflect the severity of coronary artery disease and play an important role in coronary artery plaque destabilization.

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备注/Memo

备注/Memo:
收稿日期：2009-08-09.通讯作者：曾秋棠，主任医师，主要从事介入心脏病学研究Email：zengqt139@sina.com 作者简介：刘鸿涛，硕士生Email：lht1022@yahoo.cn
更新日期/Last Update: 2010-06-22