«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2011年第1期

页码:

120-122

栏目:

临床研究

出版日期:

2010-10-27

文章信息/Info

Title:

Efficacy comparison between ¹³¹I and anti-thyroid drugs for treatment of thyrotoxic cardiopathy

作者:

云辉; 吴国超

解放军第187中心医院门诊部，海南 海口 571159

Author(s):

YUN Hui;  WU Guo-chao

Out-patient Department, PLA 187 Hospital, Haikou 571159, Hainan, China

关键词:

心脏病; 甲状腺机能亢进性; 放射性同位素碘; 抗甲状腺药物

Keywords:

cardiopathy;  thyrotoxic;  ¹³¹I;  anti-thyroid drugs

分类号:

R581.1

DOI:

-

文献标识码:

A

摘要:

目的: 比较¹³¹I与抗甲状腺药物（ATD）治疗甲亢性心脏病的临床疗效。方法: 对226例甲亢性心脏病患者分别采用¹³¹I（151例）及ATD（75例）治疗，比较两组病例的临床疗效、治疗前后甲状腺激素水平、心电图及超声心动图变化情况。结果: ¹³¹I组的总有效率显著高于ATD组（P<0.01)；且心功能改善及心电图好转率均显著高于ATD组（均P<0.01)。超声心动图检查：¹³¹I组患者LVEF、LVEDD、LVESD、SV及CO治疗后较治疗前显著改善(P<0.01)；ATD组治疗前后差异无统计学意义；治疗后两组指标相比差异有统计学意义（P<0.01)。两组治疗后甲状腺激素水平较治疗前均显著降低（P<0.01)，但两组治疗后甲状腺激素水平相比无统计学意义。131I组甲状腺功能减退（甲减）发生率显著高于ATD组（17% vs. 0%,P<0.01）。结论: ¹³¹I治疗甲亢性心脏病综合疗效优于ATD，缺点是甲减发生率高。

Abstract:

AIM: To compare the efficacy between ¹³¹I and anti-thyroid drugs (ATD) for treatment of thyrotoxic cardiopathy. METHODS: Two hundred and twenty-six patients with thyrotoxic cardiopathy were treated, respectively, with ¹³¹I (151 cases) and ATD (75 cases). Efficacy, changes of thyroid hormones, and results of electrocardiogram and echocardiogram were compared between groups. RESULTS: The total effective rate of ¹³¹I group was higher than the ATD group (P<0.01) and the improvement of cardiac function and electrocardiogram in ¹³¹I group was better than that in ATD group (P<0.01). Significant improvement was found in the levels of LVEF, LVEDD, LVESD, SV and CO before and after treatment in ¹³¹I group (P<0.01). No significant difference was observed in the results of echocardiogram before and after treatment in ATD group and no significant difference was seen in the results of echocardiogram between groups (P<0.01). Obvious descent was observed in the level of thyroid hormones after treatment compared with that before treatment in each group (P<0.01). But no significant difference was observed after treatment between groups. The incidence of hypothyroidism in ¹³¹I group was higher than that in ATD group (17% vs. 0%, P<0.01). CONCLUSION: ¹³¹I is more effective than ATD in the treatment of thyrotoxic cardiopathy but with a higher incidence of hypothyroidism.

参考文献/References

[1]梁华举，马玉琴，种冠峰，等. 131I治疗甲亢性心脏病108例临床分析[J]. 中国地方病防治杂志， 2008， 23（3）：235-237.

[2]赵明，于景，宋华，等. 放射性131I治疗甲亢性心脏病的疗效评价[J]. 中国医师杂志, 2005， 7（9）：1286-1287.

[3]韦智晓，覃伟武，李俊红，等. (131)碘治疗甲亢性心脏病的763例临床分析[J]. 广西医学院学报， 2008， 25（3）：457-458.

[4]金毅. 131I治疗甲亢性心脏病[J]. 医学信息， 2006， 19（1）：131-132.

备注/Memo

备注/Memo:

收稿日期：2010-02-23.作者简介：云辉,主治医师Email:lsb_2000@126.com

常用功能

更新日期/Last Update: 2010-10-27