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Title:: -

作者:: 梁卓¹; 2; 姚天明³; 刘丽凤⁴; 韩雅玲¹; 1.沈阳军区总医院心血管内科,辽宁沈阳 110016；2.第四军医大学西京医院心血管内科,陕西西安 710032； 3.辽宁中医药大学心血管内科,辽宁沈阳 110016；4.解放军总医院心血管内科，北京 100853

Author(s):: -

关键词:: miRNA; 血小板

Keywords:: -

分类号:: R331.1

DOI:: -

文献标识码:: A

摘要:: 血栓和出血性疾病一直危害着人类的健康，血小板在其中起着关键性的作用。微小RNA(miRNA)是一类内源性非编码的小RNA，在人体生命活动中具有非常广泛的调节功能。目前发现，部分miRNA在血小板内表达，并且参与调节血小板内部相关基因的表达，为血小板内部分子机制的研究提供了一个新的途径，为血栓和出血性疾病的诊断和治疗也可能提供一种新的方法。现就miRNA与血小板相关的研究进展作一综述。

Abstract:: -

参考文献/References

[1]Thum T, Catalucci D, Bauersachs J. MicroRNAs: novel regulators in cardiac development and disease[J]. Cardiovasc Res, 2008, 79(4):562-570.

[2]Hutvagner G, Simard MJ. Argonaute proteins: key players in RNA silencing[J]. Nat Rev Mol Cell Biol, 2008, 9(1):22-32.

[3]Ruby JG, Jan CH, Bartel DP. Intronic microRNA precursors that bypass Drosha processing[J]. Nature, 2007, 448(7149):83-86.

[4]Okamura K, Hagen JW, Duan H, et al. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila[J]. Cell, 2007, 130(1):89-100.

[5]Berezikov E, Chung WJ, Willis J, et al. Mammalian mirtron genes[J]. Mol Cell, 2007, 28(2):328-336.

[6]Bartel DP. MicroRNAs: target recognition and regulatory functions[J]. Cell, 2009, 136(2):215-233.

[7]Brodersen P, Voinnet O. Revisiting the principles of microRNA target recognition and mode of action[J]. Nat Rev Mol Cell Biol, 2009, 10(2):141-148.

[8]Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?[J]. Nat Rev Genet, 2008, 9(2):102-114.

[9]Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs[J]. Cell, 2009, 136(4):642-655.

[10]Vasudevan S, Steitz JA. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2[J]. Cell, 2007, 128(6):1105-1118.

[11]Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation[J]. Science, 2007, 318(5858):1931-1934.

[12]Orom UA, Nielsen FC, Lund AH. MicroRNA-10a binds the 5UTR of ribosomal protein mRNAs and enhances their translation[J]. Mol Cell, 2008, 30(4):460-471.

[13]Henke JI, Goergen D, Zheng J, et al. microRNA-122 stimulates translation of hepatitis C virus RNA[J]. EMBO J, 2008, 27(24):3300-3310.

[14]Evangelista V, Manarini S, Di Santo A, et al. De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin[J]. Circ Res, 2006, 98(5):593-595.

[15]Landry P, Plante I, Ouellet DL, et al. Existence of a microRNA pathway in anucleate platelets[J]. Nat Struct Mol Biol, 2009, 16(9):961-966.

[16]Merkerova M, Belickova M, Bruchova H. Differential expression of microRNAs in hematopoietic cell lineages[J]. Eur J Haematol, 2008, 81(4):304-310.

[17]Kannan M, Mohan KV, Kulkarni S, et al. Membrane array-based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis[J]. Transfusion, 2009, 49(7):1443-1450.

[18]Kondkar AA, Bray MS, Leal SM, et al. VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA[J]. J Thromb Haemost, 2010, 8(2):369-378.

[19]Ren Q, Ye S, Whiteheart SW. The platelet release reaction: just when you thought platelet secretion was simple[J]. Curr Opin Hematol, 2008, 15(5):537-541.

[20]Shiffman D, OMeara ES, Bare LA, et al. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study[J]. Arterioscler Thromb Vasc Biol, 2008, 28(1):173-179.

[21]Shiffman D, Rowland CM, Louie JZ, et al. Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction[J]. Arterioscler Thromb Vasc Biol, 2006, 26(7):1613-1618.

[22]Michelson AD, Frelinger AR, Furman MI. Current options in platelet function testing[J]. Am J Cardiol, 2006, 98(10A):4N-10N.

[23]Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection[J]. Proc Natl Acad Sci USA, 2008, 105(30):10513-10518.

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miRNA与血小板

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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