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急性冠脉综合征患者血清氮末端脑钠尿肽原水平与冠脉病变程度的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第5期
页码:
629-632
栏目:
临床研究
出版日期:
2011-10-25

文章信息/Info

Title:
Association between serum NT-proBNP levels and severity of coronary artery lesions in patients with acute coronary syndromes
作者:
王爱萍1; 张焕轶1; 杨曙光2; 吴 云1; 王咏梅1; 张代民2
1.泰安市中心医院心内科，山东 泰安 271000；2.解放军第88医院心内科，山东 泰安 271000
Author(s):
WANG Ai-ping1;  ZHANG Huan-yi1;  YANG Shu-guang2;  WU Yun1;  WANG Yong-mei1;  ZHANG Dai-min2
1.Department of Cardiology, Taian Central Hospital, Taian 271000, Shandong, China; 2.Department of Cardiology, PLA 88th Hospital, Taian 271000, Shandong, China
关键词:
急性冠脉综合征; 氮末端脑钠尿肽原; 左室射血分数; 冠状动脉造影; 冠脉病变
Keywords:
acute coronary syndromes;  serum NT-proBNP;  LVEF;  coronary artery angiography;  coronary artery lesions
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨急性冠脉综合征（ACS）患者血清氮末端脑钠尿肽原（NT-proBNP）水平与冠脉病变程度之间的关系。方法： 对150例因胸痛入院的患者行选择性冠状动脉造影，其中ACS组78例，稳定型心绞痛(SAP)组33例，冠状动脉造影正常组39例，采用冠状动脉造影Gensini积分评价冠状动脉病变的严重程度，同期测定患者血清NT-proBNP及左室射血分数（LVEF），分析NT-proBNP基线水平与LVEF及Gensini积分的关系。结果： ①ACS组NT-proBNP浓度明显高于SAP组与正常组（均P<0.05）。SAP组NT-proBNP浓度明显高于正常组（P<0.05）。②ACS患者NT-proBNP水平与Gensini积分呈正相关（Pearson偏相关系数r＝0.84，P<0.01）。③多元逐步回归结果显示，ACS患者，影响NT-proBNP浓度的因素为冠状动脉造影积分和LVEF（冠状动脉造影Gensini积分的偏决定系数R2=0.8327，P<0.01；LVEF 的偏决定系数R2=0.0034，P>0.05）。结论: ACS患者血清NT-proBNP水平与冠脉病变程度高度相关。
Abstract:
AIM:To investigate the association between serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and the severity of coronary artery lesions. METHODS: Serum NT-proBNP concentrations and left ventricular ejection fraction (LVEF) were measured in 150 patients with chest pain. All patients underwent coronary artery angiography (CAG). Severity of coronary artery lesions was estimated by coronary angiographic Gensini score. According to clinical data and results of CAG, 78 patients were diagnosed with ACS, 33 patients were diagnosed with stable angina (SA) and 39 patients were normal controls. Correlations of NT-proBNP levels with LVEF and Gensini score were analyzed. RESULTS: Serum NT-proBNP concentrations were higher in ACS patients than those in SA patients and control subjects (P<0.05, respectively). A significant difference was observed in NT-proBNP levels between SA patients and control subjects (P<0.05). NT-proBNP levels were correlated with the Gensini score in ACS (r=0.83953, P=0.0001) patients. Multiple stepwise regression analyses revealed that initial NT-proBNP levels were correlated with LVEF and Gensini score in ACS patients. Partial R2 of LVEF and Gensini score in ACS patients was, respectively, R2=0.8327 (P=0.0001) and R2=0.0034 (P=0.1035). NT-proBNP concentrations increased with the severity of coronary artery lesions in ACS group. CONCLUSION: Serum NT-proBNP level is correlated with the severity of coronary artery lesions and has significant prognostic value in ACS patients.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2011-01-12.通讯作者：杨曙光，主任医师，主要从事冠心病和心律失常的介入治疗研究 Email：qingyuw@163.com 作者简介：王爱萍，主治医师，硕士生Email：wangaiping006@163.com
更新日期/Last Update: 2011-11-03