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|本期目录/Table of Contents|

B族维生素过量与心血管病风险(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2012年第1期
页码:
110-113
栏目:
综述
出版日期:
2012-02-25

文章信息/Info

Title:
High intake of B vitamins: a risk factor for cardiovascular disease?
作者:
周士胜1; 臧益民2
(1.大连大学辽宁省高校生物物理学重点实验室，辽宁 大连 116622；2.第四军医大学生理学教研室，陕西 西安 710032)
Author(s):
ZHOU Shi-sheng1;  ZANG Yi-min2
(1.Key Laboratories of Biophysics of Liaoning Province, Institute of Basic Medical Sciences, Medical College, Dalian University, Dalian 116622, Liaoning, China; 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
B族维生素; 胰岛素抵抗; Ⅱ型糖尿病; 肥胖
Keywords:
B-vitamin;  insulin resistance;  type II diabetes;  cardiovascular disease
分类号:
R977.22
DOI:
-
文献标识码:
A
摘要:
心血管疾病是一个全球性公共健康问题。在过去几十年中，心血管病呈现出全球性快速流行趋势，原因不明。B族维生素与人体的物质和能量代谢关系密切。长期摄入过量的B族维生素对人体有何影响？未引起人们的重视。最近，我们的生态学研究结果显示，美国肥胖和糖尿病流行与人均维生素B1、B2和B3(烟酸和烟酰胺)呈显著的滞后相关关系。已有的流行病学、临床和实验室证据强烈提示，长期摄入富含B族维生素的食物，特别是维生素B3(烟酸和烟酰胺)过量，可能是增加心血管病风险的主要因素之一。
Abstract:
Cardiovascular disease is a global health problem. In recent decades there has been an alarming increase in the prevalence of cardiovascular disease but the etiology of this increase is still obscure. Recent etiological evidence has indicated that the prevalence of obesity and type 2 diabetes (key risk factors for cardiovascular disease) is correlated with B-vitamin consumption. Numerous studies have demonstrated that niacin, a major B vitamin, can induce insulin resistance and glucose intolerance. High intake of B vitamins may thus be a risk factor for cardiovascular disease. This minireview will briefly discuss the relationship between excess B-vitamin intake and risk of cardiovascular disease.

参考文献/References

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[2]周士胜,伦永志,李胜范.2型糖尿病病因可能在肝脏[J].大连大学学报,2008,29(3):89-91.

[3]Zhou SS,Li D,Zhou YM,et al.B-vitamin consumption and the prevalence of diabetes and obesity among the US adults:population based ecological study[J].BMC Public Health,2010,10:746.

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备注/Memo

备注/Memo:
收稿日期：2011-05-14.基金项目：国家自然科学基金项目资助(30570665)；辽宁省 教育厅高校重点实验室基金项目资助（2009S005）； 大连市科技局基金项目资助（2008E13SF182） 通讯作者：臧益民，教授，主要从事心血管基础研究 Email:xinzang@fmmu.edu.cn 作者简介：周士胜，教授，博士 Email:zhouss@dlu.edu.cn
更新日期/Last Update: 2012-02-14