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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2012年第1期

页码:

114-116

栏目:

综述

出版日期:

2012-02-25

文章信息/Info

Title:

Research development of biomarkers for oxidative stress in atherosclerosis

作者:

徐 敏 综述; 任雨笙 审校

(第二军医大学附属长征医院心内科，上海 200003)

Author(s):

XU Min;  REN Yu-sheng

(Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China)

关键词:

动脉粥样硬化; 氧化应激; 生物标记物

Keywords:

atherosclerosis;  oxidative stress;  biomarkers

分类号:

R543.5

DOI:

-

文献标识码:

A

摘要:

越来越多的证据表明，氧化应激在动脉粥样硬化（AS）性心血管疾病形成中的重要作用。最近的一些病理学方面的研究也发现，某些特异性的调节物参与了这些氧化应激反应并可促进AS斑块在血管壁的形成和破裂。这些特异性的调节物能在人体内测出并作为AS性心血管疾病风险评估的生物标记物，本文就这些生物标记物作一综述。

Abstract:

More and more evidence has highlighted the roles of oxidative stress in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated some specific mediators participating in oxidative stress reaction and in the promotion of the formation and rupture of atherosclerotic plaques in the artery wall. These mediators can be measured in the systemic circulation and can be used as biomarkers for risk assessment of atherosclerotic cardiovascular disease. Theses biomarkers are reviewed in this article.

参考文献/References

[1]Stephens JW,Khanolkar MP,Bain SC.The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease[J].Atherosclerosis,2009,202(2):321-329.

[2]Tsukahara H.Biomarkers for oxidative stress:clinical application in pediatric medicine[J].Curr Med Chem,2007,14(3):339-351.

[3]黄宇理,包宗明.异构前列腺素与心血管相关疾病[J].心脏杂志,2008,20(6):789-792.

[4]Basarici I,Altekin RE,Demir I,et al.Urinary 8-isoprostane levels can indicate the presence，severity and extent of angiographic eoronary artery disease[J].Acta Cardiol,2008,63(4):415-422.

[5]欧阳劭,陈 伟,陈 琳,等.8-异构前列腺素F2a与冠心病患者冠脉病变严重程度关系的研究[J].中国心血管病研究,2010,12(8):890-894.

[6]杨玉恒,夏 岳,戚国庆,等.血清对氧磷酶-1活性与冠脉Gensini积分的相关性研究[J].疑难病杂志,2007,9(6):513-515.

[7]Grundy SM.Gamma-glutamyl transferase:another biomarker for metabolic syndrome and cardiovascular risk[J].Arterioscler Thromb Vasc Biol,2007,27(1):4-7.

[8]Emdin M,Passino C,Michelassi C,et al.Additive prognostic value of gamma-glutamyltransferase in coronary artery disease[J].Int J Cardiol,2009,136(1):80-85.

[9]苗 裔,臧伟进.microRNA-21及相关技术在心血管疾病中的研究进展[J].心脏杂志,2011,23(2):255-259,265.

备注/Memo

备注/Memo:

收稿日期：2011-05-17.基金项目：上海市自然科学基金项目资助（10411963900）通讯作者：任雨笙，主任医师，主要从事冠心病的临床和基础研究 Email:renyusheng@gmail.com 作者简介：徐敏，主治医师，硕士生 Email:xumin1981cn@hotmail.com

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更新日期/Last Update: 2012-02-14