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|本期目录/Table of Contents|

MicroRNAs与心肌缺血/再灌注损伤关系的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第2期
页码:
234-237249
栏目:
综述
出版日期:
2013-04-25

文章信息/Info

Title:
Research advances in the relationship between microRNAs and myocardial ischemia/reperfusion injury
作者:
张志禹1; 冯 娜2; 郭海涛2; 李 娟2; 张淑苗2; 裴建明2
(第四军医大学：1.航空航天医学系五队，2.生理学教研室,陕西 西安 710032)
Author(s):
ZHANG Zhi-yu1;  FENG Na2;  GUO Hai-tao2;  LI Juan2;  ZHANG Shu-miao2;  PEI Jian-ming2
(1.Team 5, Faculty of Aerospace Medicine, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
microRNA; 缺血再灌注损伤; 心肌细胞凋亡; 热休克蛋白; 离子通道
Keywords:
microRNA;  myocardial ischemia reperfusion injury;  apoptosis;  heat shock protein;  ion channel
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
MicroRNA(miRNA)是一类体内生成，长度介于17~25 nt的非编码小RNA。此类RNA在翻译后的水平对基因表达发挥负调控作用，广泛参与生物体的生长发育及各种病理生理过程。近年研究表明，miRNA在心肌缺血/再灌注损伤(MIRI)中发挥重要作用，其参与了与MIRI有关的心肌细胞凋亡、热休克蛋白、离子通道以及细胞生存信号通路的调控，并可作为某些药物的作用靶点，为MIRI的治疗提供了新的思路。
Abstract:
MicroRNAs are a class of endogenous and non-coding short-length RNAs (17-25 nt). MicroRNAs act as post-transcriptional negative regulators of gene expression, which is important in the regulation of growth, development and various pathological progresses. Recent studies show that microRNAs are important in the regulation of myocardial ischemia reperfusion injury (MIRI) such as apoptosis, heat shock protein, ion channel, cell survival pathway and potential therapeutic targets for treatment. These studies provide a new approach to the treatment of MIRI.

参考文献/References

[1]Guarnieri DJ,DiLeone RJ.MicroRNAs:a new class of gene regulators[J].Ann Med,2008,40(3):197-208.
[2]Bartel,DP.MicroRNAs:target recognition and regulatory functions[J].Cell,2009,136(2):215-233.
[3]Yin C,Wang X,Kukreja RC.Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice[J].FEBS Lett,2008,582(30):4137-4142.
[4]Zhao ZQ,Zang YM.Alternative cardioprotective strategy during reperfusion: postconditioning vs preconditioning[J].心脏杂志,2006,18(1):1-7,13.
[5]Cheng Y,Zhu P,Yang J,et al.Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4[J].Cardiovasc Res,2010,87(3):431-439.
[6]He B,Xiao J,Ren AJ,et al.Role of miR-1 and miR-133a in myocardial ischemic postconditioning[J].J Biomed Sci,2011,18:22.
[7]Tang X,Gal J,Zhuang X,et al.A simple array platform for microRNA analysis and its application in mouse tissues[J].RNA,2007,13(10):1803-1822.
[8]van Rooij E,Quiat D,Johnson BA,et al.A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance[J].Dev Cell,2009,17(5):662-673.
[9]Wang JX,Jiao JQ,Li Q,et al.miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1[J].Nat Med,2011,17(1):71-78.
[10]Sano M,Minamino T,Toko H,et al.p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload[J].Nature,2007,446(7134):444-448.
[11]Wang X,Zhang X,Ren XP,et al.MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury[J].Circulation,2010,122(13):1308-1318.
[12]Ren XP,Wu J,Wang X,et al.MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20[J].Circulation,2009,119(17):2357-2366.
[13]Sayed D,He M,Hong C,et al.MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand[J].J Biol Chem,2010,285(26):20281-20290.
[14]Luo X,Zhang H,Xiao J,et al.Regulation of human cardiac ion channel genes by microRNAs:theoretical perspective and pathophysiological implications[J].Cell Physiol Biochem,2010,25(6):571-586.
[15]Aurora AB,Mahmoud AI,Luo X,et al.MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death[J].J Clin Invest,2012,122(4):1222-1232.
[16]Ye Y,Hu Z,Lin Y,et al.Downregulation of microRNA-29 by antisense inhibitors and a PPAR-g agonist protects against myocardial ischaemia-reperfusion injury[J].Cardiovasc Res,2010,87(3):535-544.
[17]Mukhopadhyay P,Mukherjee S,Ahsan K,et al.Restoration of altered microRNA expression in the ischemic heart with resveratrol[J].PLoS One,2010,5(12):e15705.
[18]Thum T,Gross C,Fiedler J,et al.MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibro-blasts[J].Nature,2008,456(7224):980-984.
[19]Cascio S,D'Andrea A,Ferla R,et al.miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells[J].J Cell Physiol,2010,224(1):242-249.
[20]Guttilla IK, White BA. Coordinate regulation of FOXO1 by miR-27a,miR-96,and miR-182 in breast cancer cells[J].J Biol Chem,2009,284(35):23204-23216.
[21]Saunders LR,Sharma AD,Tawney J,et al.miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues[J].Aging(Albany NY),2010,2(7):415-431.
[22]Gustafsson AB,Gottlieb RA.Recycle or die:The role of autophagy in cardioprotection[J].J Mol Cell Cardiol,2008,44(4):654-661.
[23]Xiao J,Zhu X,He B,et al.MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II[J].J Biomed Sci,2011,18:35.
[24]Fu Y,Zhang Y,Wang Z,et al.Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy[J].Am J Nephrol,2010,32(6):581-589.

备注/Memo

备注/Memo:
收稿日期：2012-09-26.基金项目：国家自然科学基金项目资助（81270402,30971060, 31100827,30900535,31200875）；陕西省自然科学基金项目资助（2010K01195，2011JM4001）;陕西省 科学技术研究发展计划项目资助(S2010SF883) 通讯作者：裴建明，教授，主要从事心脏保护研究 Email:jmpei8@fmmu.edu.cn 作者简介：张志禹，本科生 Email:zzy901128@163.com 共同第一作者：冯娜，助理实验师 Email:cxnna@163.com
更新日期/Last Update: 2013-04-28