糖尿病性心肌病发病的统一机制——氧化应激
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2013年第2期
- 页码:
- 246-249
- 栏目:
- 综述
- 出版日期:
- 2013-04-25
文章信息/Info
- Title:
- Unifying mechanism of diabetic cardiomyopathy-oxidative stress
- Author(s):
- HUANG Hai; SONG Cheng-yun; LI Yun-tian
- (Center of Cardiology, PLA 305 Hospital, Beijing 100017, China)
- Keywords:
- diabetic cardiomyopathy; oxidative stress; pathogenesis
- 分类号:
- R542.2
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 越来越多的证据表明，氧化应激是糖尿病性心肌病（DCM）的统一发病机制。本文就氧化应激引起DCM的病理生理机制进行了综述，提示DCM患者使用胰岛素泵强化治疗后氧化应激水平明显降低。
- Abstract:
- Ongoing evidence suggests that the unifying mechanism of diabetic cardiomyopathy (DCM) is oxidative stress. This article reviews the pathophysiological mechanisms of DCM caused by oxidative stress and suggests that the oxidative stress level in DCM patients significantly decreases after continuous subcutaneous insulin infection treatment.
参考文献/References
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[2]Giacco F,Brownlee M.Oxidative stress and diabetic complications[J].Circ Res,2010,107(9):1058-1070.
[3]Duncan JG.Mitochondrial dysfunction in diabetic cardiomyopathy[J].Biochim Biophys Acta,2011,1813(7):1351-1359.
[4]Aneja A,Tang WH,Bansilal S,et al.Diabetic cardiomyopathy:in-sights into pathogenesis,diagnostic challenges, and therapeutic options[J].Am J Med,2008,121(9):748-757.
[5]Ma H,Li SY,Xu P,et al.Advanced glycation endproduct(AGE)accumulation and AGE receptor(RAGE)upregulation contribute to the onset of diabetic cardiomyopathy[J].J Cell Mol Med,2009,13(8B):1751-1764.
[6]Lorenzo O,Picatoste B,Ares-Carrasco S,et al.Potential role of nuclear factor κB in diabetic cardiomyopathy[J].Mediators Inflamm,2011,2011:652097.
[7]黄 海,宋成运,杜大勇,等.糖尿病性心肌病变患者胰岛素强化治疗前后氧化应激水平的变化[J].心脏杂志,2012,24(5):606-608.
备注/Memo
- 备注/Memo:
- 收稿日期：2011-11-19.通讯作者：李运田，主任医师，主要从事冠脉介入和心肌病的基础及临床研究 Email：lyt305@126.com 作者简介：黄海，主治医师，硕士 Email：hhbrood@hotmail.com
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