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|本期目录/Table of Contents|

细胞程序性坏死与心血管疾病的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2013年第4期
页码:
476-481
栏目:
综述
出版日期:
2013-07-25

文章信息/Info

Title:
Research advance in relationship between programmed cell necrosis and cardiovascular disease
作者:
李 晨1; 殷 玥2综述; 马 恒2审校
(第四军医大学：1.口腔医学系学员六队，2.生理学教研室，陕西 西安710032)
Author(s):
LI Chen1;  YIN Yue2;  MA Heng2
(1.Team 6, School of Stomatology, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
细胞程序性坏死; 细胞凋亡; 心肌缺血; 心衰
Keywords:
necroptosis;  apoptosis;  myocardial ischemia;  heart failure
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
细胞凋亡是研究最为深入的细胞程序性死亡方式。但是近年发现，细胞中尚存在非凋亡性的程序性死亡机制。以往认为，细胞坏死是被动的细胞事件并且难以有效控制。新近发现的程序性坏死（necroptosis）作为一种死亡受体介导的半胱氨酸天冬氨酸蛋白酶(caspase)非依赖性细胞死亡模式为细胞死亡机制学说带来了重大突破。许多研究报道相继表明，细胞程序性坏死同样是受细胞内信号因子严密调控的主动过程。心肌细胞的坏死和凋亡是心脏疾病的重要病理途径。本文综述了心肌缺血与心衰过程中程序性坏死的作用及其与心肌细胞凋亡的关系，并探讨了针对心肌细胞程序性坏死的潜在治疗方向。
Abstract:
It is known that apoptosis is an actively mediated programmed cell death. However, in recent years, non-apoptotic programmed cell death has been recognized. Necrosis has traditionally been regarded as passive and unregulated and the newly discovered necroptosis is a death receptor mediated caspase-independent cell death. A large number of studies showed that necroptosis is an active process which is regulated by intracellular signal factors and myocardial cell necrosis and apoptosis are important pathological processes of heart diseases. This review discusses the role of necroptosis in myocardial ischemia and heart failure, its relationship with apoptotic pathways and new therapeutic opportunities the regulated necroptosis presents.

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备注/Memo

备注/Memo:
收稿日期：2012-10-12.通讯作者：马恒，副教授，主要从事心肌内源性保护机制研究 Email：hengma@fmmu.edu.cn 作者简介：李晨，本科生 Email：diyisun1115@163.com 共同第一作者：殷玥，助理实验师 Email：yiny@qq.com
更新日期/Last Update: 2013-07-29