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Title:: Effects of adriamycin on cardiac structure and serum NTproBNP in rabbits

作者:: 蔡虎志¹; 陈青扬¹; 陈新宇²; (1.湖南中医药大学研究生院，湖南长沙 410208，2.湖南中医药大学第一附属医院，湖南长沙 410007)

Author(s):: CAI Hu zhi¹; CHEN Qing yang¹; CHEN Xin yu²; (1.Graduate School, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan, China; 2.First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan, China)

关键词:: 阿霉素; 心脏结构; 氨基末端脑钠尿肽前体; 兔

Keywords:: adriamycin; cardiac structure; Nterminal brain natriuretic peptide precursor; rabbit

分类号:: R979.14

DOI:: -

文献标识码:: A

摘要:: 目的:探讨阿霉素（ADR）对兔心脏结构及血清氨基末端脑钠尿肽前体（NT-proBNP）的影响，为慢性心衰模型的建立提供理论依据。方法:新西兰兔30只，随机分成正常对照组、模型4周组和模型8周组，每组10只（n=10）。模型4、8周组：耳缘静脉注射ADR(1.0 mg/kg，用生理盐水配制成1.0 mg/ml溶液)，每周2次，共4、8周，正常对照组：注射相同体积的生理盐水。各组于末次注射7 d后，测量其左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、室间隔厚度（IVS）和左室后壁厚度（LVPW），并检测血清NT-proBNP水平的变化。结果:与正常对照组相比，模型4、8周两组LVDd、LVDs、IVS及LVPW均有不同程度增大（P<0.05或P<0.01），血清NT-proBNP的水平明显升高（P<0.01）。结论:ADR常规剂量长期静脉注射4、8周，可致兔心脏结构及血清NTproBNP水平明显变化，可用于慢性心衰模型的制作。

Abstract:: AIM:To study the effects of adriamycin (ADR) on cardiac structure and serum Nterminal brain natriuretic peptide precursor (NTproBNP) in rabbits and provide a model for chronic heart failure. METHODS: Thirty rabbits were randomly divided into three groups: 4week model group (n=10) and 8week model group (n=10, each) in which ADR was intravenously injected at the doses of 1 mg/kg twice weekly for 4 or 8 weeks, and control group (n=10) in which an equivalent volume of 09% sodium chloride was given. Seven days after the final injection in each group, the left ventricular enddiastolic dimension (LVEDD), left ventricular endsystolic dimension (LVESD), interventricular septum (IVS), left ventricular posterior wall (LVPW) and serum NTproBNP were evaluated, respectively. RESULTS: Compared with those in control group, LVDd, LVDs, IVS, LVPW and serum NTproBNP increased obviously in both model groups. CONCLUSION: Chronic administration of intravenous ADR to rabbits for 4 or 8 weeks harms the cardiac structure and raises serum NTproBNP. A model of chronic heart failure can be induced by ADR.

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阿霉素对兔心脏结构及血清氨基末端脑钠尿肽前体的影响

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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