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|本期目录/Table of Contents|

心脏转录因子GATA4与心房颤动的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第3期
页码:
344-347
栏目:
综述
出版日期:
2014-03-20

文章信息/Info

Title:
Relationship between cardiac transcription factor GATA4 and atrial fibrillation
作者:
丁媛媛1; 王 倩2; 杨奕清2
(1.上海市医学科学技术情报研究所，上海 200031；
2.上海交通大学附属胸科医院心内科、心血管研究室、中心实验室，上海 200030)
Author(s):
DING Yuan yuan1;  WANG Qian2;  YANG Yi qing2
(1.Shanghai Medical Information Center, Shanghai 200031, China;
2.Department of Cardiology, Cardiovascular Research Laboratory & Central Laboratory, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China)
关键词:
心房颤动; 遗传学; 心脏转录因子
Keywords:
atrial fibrillation;  genetics;  transcriptional factor
分类号:
R541.75
DOI:
-
文献标识码:
A
摘要:
心脏转录因子GATA4是一种在心脏中大量表达的锌指转录因子，在心血管发育、心肌重构与肌细胞凋亡方面发挥着重要的生理作用，GATA4基因突变可导致多种先天性心脏病。近年来的研究显示，GATA4基因突变也可导致心房颤动（AF）。本文拟就GATA4的生理功能及其与AF的关系进行综述，旨在便于理解AF新的分子机制，从而有助于AF的早期预防和个体化治疗。
Abstract:
GATA4 is a zinc fingercontaining transcriptional factor highly expressed in the heart and plays an important physiological role in cardiovascular development, myocardial remodeling and cellular apoptosis. Mutations in the GATA4 gene have been implicated in various kinds of congenital heart diseases. Recent studies demonstrated that GATA4 mutations also lead to atrial fibrillation (AF). In this paper the physiological function of GATA4 and its association with AF are reviewed for a better understanding of the novel molecular mechanism involved in the pathogenesis of AF and the early prophylaxis and personalized treatment of AF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-10-21.
基金项目：国家自然科学基金项目资助（30570768，81070153，81270161）；上海市自然科学基金项目资助 （10ZR1428000）
通讯作者：杨奕清，研究员，主要从事心血管疾病发生机制与干预策略研究 Email：dryyq@tongji.edu.cn
作者简介：丁媛媛，副编审，硕士 Email：dingyy2001@sina.com
更新日期/Last Update: 2014-03-21