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|本期目录/Table of Contents|

心脏成纤维细胞的旁分泌功能

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第3期
页码:
353-356
栏目:
综述
出版日期:
2014-03-20

文章信息/Info

Title:
Paracrine action of myocardial fibroblast myocytes
作者:
张 鹏1; 李国华2; 李佳妮2; 董 玲2
(1.兰州军区乌鲁木齐总医院骨科，新疆 乌鲁木齐 830000；
2.第四军医大学基础部生理学教研室，陕西 西安 710032)
Author(s):
ZHANG Peng1;  LI Guo hua2;  LI Jia ni2;  DONG Ling2
(1.Department of Orthopedic Surgery, Urumqi General Hospital, Urumqi 830000, Xinjiang, China;
2.Depatrment of Physiology, School of Basic Medical Sciences, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
心脏成纤维细胞; 心衰; 旁分泌
Keywords:
cardiac fibrobalst;  heart failure;  paracrine
分类号:
R329.25
DOI:
-
文献标识码:
A
摘要:
心脏成纤维细胞(cardiac fibroblasts，CFs)是心脏正常功能和感受心脏应激和损伤的重要成分。越来越多的证据表明，CFs不仅可以生成心肌细胞生存的基质，而且对于心脏的电生理特性、收缩都有重要的作用。更为重要的是，CFs还在病理和生理的重构中担当重要角色。CFs可以通过旁分泌机制影响心肌细胞。因此，更好地了解细胞间的相互作用有助于寻找诸如心衰这类疾病的治疗靶点。
Abstract:
Cardiac fibroblasts are key components of normal cardiac functions and the response to stressors and injury. Increasing evidence shows that cardiac fibroblasts play an important role in matrix production and cardiac function including cardiac electrophysiology and contractility. Cardiac fibroblasts interact with myocytes via paracrine mechanism. A better understanding of cardiac fibroblasts may develop into a novel treatment for heart failure.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2013-09-03.
基金项目：国家科技重大项目专项资助(2009ZX09301009)；陕西省中医管理局中医药科研项目资助(jc 38)
通讯作者：董玲，副教授，主要从事糖尿病与心血管损害研究 Email：dongling@fmmu.edu.cn
作者简介：张鹏，主治医生 Email：zhang709@fmmu.edu.cn
更新日期/Last Update: 2014-03-21