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Title:: Relationship between fractalkine level and severity of coronary heart disease

作者:: 夏金喜; 肖建民; (暨南大学附属东莞医院心内科，广东东莞 523900)

Author(s):: XIA Jin-xi; XIAO Jian-min; (Department of Cardiology, Jinan University Affiliated Hospital of Dongguan, Dongguan, Guangdong 523900, China)

关键词:: 冠状动脉疾病; 炎症趋化因子类; fractalkine

Keywords:: coronary disease; chemokines; fractalkine

分类号:: R541.4

DOI:: -

文献标识码:: A

摘要:: 目的:探讨Fractalkine血清水平与冠心病病情严重程度之间的关系。方法：入选冠状动脉造影(CAG)确诊的冠心病患者90例，根据临床情况分为急性心肌梗死(AMI)32例，不稳定型心绞痛(UAP)36例，稳定型心绞痛(SAP)22例，另设CAG排除冠心病的患者30例作为对照组；依据CAG结果分为单支、两支、多支病变组；观察各组血清Fractalkine水平。结果：冠心病组Fractalkine水平均显著高于对照组，冠心病3组血清Fractalkine水平，SAP组、UAP组、AMI组依次增高；血清Fractalkine水平与冠状动脉病变支数明显呈正相关。结论： Fractalkine水平在一定程度上与冠状动脉病情及病变严重程度有关。

Abstract:: AIM:To investigate the correlation between the fractalkine level in serum and the severity of coronary heart disease (CHD). METHODS: Ninety patients with CHD diagnosed by CAG, including 32 AMI patients, 36 UAP patients and 22 SAP patients were enrolled in the study. An additional 30 healthy subjects were regarded as the control group. Patients were divided into single-lesion group, two-lesion group and multivessel lesions group. Plasma levels of soluble fractalkine were measured by enzyme-linked immunosorbent assay. RESULTS: Fractalkine plasma levels of CHD group were higher than that of control group. Fractalkine levels of SAP group, UA group and AMI group increased gradually. There was a significantly negative correlation between serum levels of fractalkine and coronary artery lesion counts. CONCLUSION: Fractalkine level in serum may be related with the severity of coronary heart diseases.

参考文献/References

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血清Fractalkine水平与冠心病病情的关系

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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