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|本期目录/Table of Contents|

线粒体融合蛋白2在心血管疾病中的研究现状

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第2期
页码:
224-228
栏目:
综述
出版日期:
2014-10-25

文章信息/Info

Title:
Mitofusin-2 in cardiac diseases
作者:
张洋洋1; 裴海峰1; 3; 段海霞4; 贾 敏2; 王 强3; 杨永健3; 陶 凌1
(第四军医大学：1.西京医院心血管内科，2.基础部生理学教研室，陕西 西安 710032；
3.成都军区 总医院心内科，四川 成都 610083；
4.西安交通大学医学院附属广仁医院，陕西 西安 710004)
Author(s):
ZHANG Yang-yang1;  PEI Hai-feng1; 3;  DUAN Hai-xia4;  JIA Min2;  WANG Qiang3;  YANG Yong-jian3;  TAO Ling1
(1.Department of Cardiology, Xijing Hospital, 2.Department of Physiology, Fourth Military Medical University, Xi’an 710032, Shaanxi, China；
3.Department of Cardiovascular Medicine, Chengdu General Hospital, Chengdu Military Area Command, Chengdu 6100
关键词:
线粒体融合蛋白2; 内质网; 线粒体自噬; 心血管疾病
Keywords:
mitofusin-2;  endoplasmic reticulum;  mitophagy;  cardiac diseases
分类号:
R541
DOI:
-
文献标识码:
A
摘要:
线粒体是一个处于不断地融合与分裂过程中的动态细胞器。线粒体融合蛋白2(Mfn2)作为广泛分布于线粒体外膜和线粒体结合内质网膜上具有多重功能的蛋白，参与维持正常细胞功能。除了参与线粒体融合外，Mfn2还能够调节线粒体代谢、促进损伤线粒体的自噬、增强线粒体与内质网交流、维持内质网功能及通过调控线粒体外膜通透性和渗透性钙转运孔道的启闭参与细胞死亡过程等。另外，Mfn2基因还可通过调控Ras-Raf-ERK/MAPK和Ras-PI3K-Akt信号通路分别参与调控血管平滑肌细胞的增殖和凋亡过程。Mfn2的这一系列重要的生物学功能有助于其参与高血压、肺动脉高压、动脉粥样硬化、急性缺血/再灌损伤、扩张性心肌病、心肌肥大、心衰和肥胖糖尿病等多种心血管疾病的发生发展过程。研究Mfn2与心血管疾病的相关性也许能为临床提供一个心血管疾病潜在治疗的靶点。因此，本文将综述Mfn2在心血管疾病相关研究中的现状。
Abstract:
Mitochondria are highly dynamic organelles with constant fusion and fission. Mitofusin-2 (Mfn2) is widely distributed on the outer membrane of mitochondria and mitochondria-associated endoplasmic reticulum membrane (MAM) with multiple functions to sustain normal cell function. In addition to promoting mitochondrial fusion, Mfn2 also participates in injured mitochondria mitophagy, tethers endoplasmic reticulum (ER) to mitochondria, sustains ER structure and functions and plays critical roles in several cell death pathways (including apoptosis and necrotic cell death) by mediating mitochondrial outer membrane permeabilization and facilitating opening of the mitochondrial permeability pore (mPTP) during death. Moreover, Mfn2 gene regulates vascular smooth muscle cell (VSMC) proliferation via Ras-Raf-ERK/MAPK and Ras-PI3K-Akt pathways. Mfn2 is associated with cardiac diseases including hypertension, pulmonary artery hypertension, atherosclerosis, dilated cardiomyopathy, acute ischemic reperfusion injury, cardiac hypertrophy, heart failure and major metabolic disturbance such as diabetes and obesity. Exploration of the relationships between Mfn2 and cardiac diseases may provide therapeutic potentials for cardiac diseases.

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备注/Memo

备注/Memo:
收稿日期：2014-05-20.
基金项目：国家杰出青年科学基金项目资助(81225001)
通讯作者：陶凌，教授，主要从事心脏缺血/再灌注损伤机制研究 Email：lingtao2006@gmail.com 共同
通讯作者：杨永健，教授，主要从事心衰基础与临床研究 Email: yangyongjian38@sina.com
作者简介：张洋洋，本科生 Email：zyy19930810@ gmail.com 共同第一作者：裴海峰，博士生 Email：haifengpe
更新日期/Last Update: 2014-11-18