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Title:: Expression of heat shock protein 70 in atrial tissue of patients with chronic heart failure

作者:: 田倪妮¹; 魏玲¹; 李宏键²; 陈黔³; 陈韦强¹; 王欢¹; 倪茂娥⁴; （成都军区昆明总医院:1.地方干部病房，3.控感科,云南昆明 650032；
2.云南省第一人民医院骨科,云南昆明 650034；
4.开远市人民医院儿科,云南开远 661600）

Author(s):: TIAN Ni-ni¹; WEI Ling¹; LI Hong-jian²; CHEN Qian³; CHEN Wei-qiang¹; WANG Huan¹; NI Mao-e⁴; (1.Wards for Civilian Cadres, 3.Infection Control Center, Kunming General Hospital, Chengdu Military Area Command, Kunming 650032, Yunnan, China；
2.Department of Orthopedics, First People’s Hospital, Kunming 650034, Yunnan, China；
4.Department of Pediatrics, People’s Hospital, Kaiyuan 661600, Yunnan, China)

关键词:: 热休克蛋白70; 心力衰竭; 慢性; 年龄; 病程

Keywords:: heat shock protein 70; chronic heart failure; age; years of disease

分类号:: R541.6

DOI:: -

文献标识码:: A

摘要:: 目的:观察慢性心力衰竭患者心肌热休克蛋白(HSP70)的表达。方法: 60例手术患者分为3组，其中心功能1级组20例，心功能2级组20例，心功能3级组20例。采用实时荧光定量（RT-PCR）方法检测HSP70的mRNA表达量。结果:①与心功能1级患者比较，HSP70 mRNA 水平在心功能2级、心功能3级组的心肌组织中表达明显减少（均P<0.05），且在心功能3级组较心功能2级组明显减少（P<0.05）。②HSP70 mRNA水平与慢性心力衰竭患者年龄、病程呈负相关。结论:慢性心力衰竭患者心肌HSP70的表达减少，可能与HSP70随着心功能恶化其保护作用减弱有关。

Abstract:: AIM:To explore the expression of heat shock protein (HSP) 70 in atrial tissue of patients with chronic heart failure (CHF). METHODS: Right atrial tissue was taken from 60 patients undergoing cardiac surgery. Patients were equally divided into NYHA I group, NYHA II group and NYHA III group (n=20, each). mRNA level of HSP70 was detected by real-time fluorescence quantitative PCR method. RESULTS: mRNA level of HSP70 significantly decreased in both NYHA II group and NYHA III group compared with NYHA I group (both P<0.05). mRNA level of HSP70 significantly decreased in NYHA III group compared with NYHA II group (P<0.05). mRNA level of HSP70 was negatively correlated with age and years of disease in CHF patients. CONCLUSIONS: HSP70 expression decreases in CHF patients, indicating that the protective effect of HSP70 weakens with the degree of increasing disease severity.

参考文献/References

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心肌热休克蛋白70在慢性心力衰竭患者中的表达

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

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