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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2015年第4期

页码:

464-466

栏目:

临床研究

出版日期:

2015-04-20

文章信息/Info

Title:

Clinical analysis of Benner Pury during acute exacerbation of chronic pulmonary heart disease

作者:

都 渝

(青海省心脑血管病专科医院，青海 西宁 810012)

Author(s):

DU Yu

(Qinghai Hospital of Cardio-cerebrovascular Disease, Xining 810012, Qinghai, China)

关键词:

肺源性心脏病; 急性加重期; 心力衰竭; 合理用药方案

Keywords:

pulmonary heart disease;  acute exacerbation;  heart failure;  rational drug use

分类号:

R541.5

DOI:

-

文献标识码:

A

摘要:

目的 观察慢性肺源性心脏病(CPHD)急性加重期患者并发心力衰竭应用贝那普利的临床疗效。方法 将2011年9月~2014年1月我院呼吸内科收治的90例CPHD急性加重期并发心力衰竭患者采用随机数字表法分为试药组和常规组各45例，常规组采用抗感染、利尿、吸氧、祛痰、扩管等常规治疗，试药组在常规治疗基础上加用贝那普利；比较两组患者治疗前与治疗后8周后血气分析、心功能及疗效情况。结果 与治疗前比较，二组动脉血氧分压(PaO2)、动脉血氧饱和度(SpO2)、pH均显著升高，动脉血二氧化碳分压(PaCO2)显著降低（P<0.05）；二组每搏量(SV)、左室射血分数(LVEF)、心排出量(CO)、肺动脉压(PAP)、心指数(CI)较治疗前均显著好转（P<0.05）。与常规组相比较，治疗后试药组在SV、LVEF、CO、CI显著增加、PAP显著降低(P<0.05)；试药组的疗效率(69%)显著高于常规组(42%，P<0.05)。试药组的总有效率(93%)高于常规组(80%),但差异未达到显著水平。结论 CPHD急性加重期并发心力衰竭患者采用常规治疗方案联合贝那普利对改善患者的心功能及提高疗效有显著作用。

Abstract:

AIM To observe the clinical effect of Benner Pury in patients with chronic pulmonary heart disease (CPHD) complicated with heart failure during acute exacerbation. METHODS Ninety exacerbated CPHD cases complicated with heart failure were randomly divided into treatment group and conventional group, with 45 cases in each group. The patients in the conventional group received conventional treatment of anti-infection, diuretics, oxygen, expectorant and tube expanding. Patients in the treatment group received conventional treatment plus Benner Pury. Blood gas analysis, heart functions and efficacy before and 8 weeks after treatment were compared between groups. RESULTS After treatment, arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SpO2) and pH significantly increased and arterial carbon dioxide partial pressure (PaCO2) decreased significantly in both groups. Stroke volume (SV), left ventricular ejection fraction (LVEF), cardiac output (CO), pulmonary artery pressure (PAP) and cardiac index (CI) were significantly better than those before treatment (P<0.05). Compared with those in the conventional group, SV, LVEF, CO and CI in the treatment group increased significantly and PAP decreased significantly (P<0.05). The effective rate in the treatment group was significantly higher (69% vs. 42%) and no effective rate was significantly lower (6.67% vs. 20%) than those in conventional group (P<0.05). The total effective rate in the treatment group was higher than in the conventional group (93% vs. 80%), but no significant difference was found between groups. CONCLUSION Conventional therapy combined with Benner Pury can significantly improve cardiac functions and effective rate in COPD patients complicated with heart failure during acute exacerbation.

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备注/Memo

备注/Memo:

收稿日期：2014-10-08.
作者简介：都渝,主治医师 Email：wan965351030@163.com

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更新日期/Last Update: 2015-04-22