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|本期目录/Table of Contents|

微小RNAs 在心肌肥厚中的作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2015年第5期
页码:
621-623
栏目:
综述
出版日期:
2015-05-05

文章信息/Info

Title:
Role of miRNAs in cardiac hypertrophy
作者:
单丽娜; 杨 巍
（哈尔滨医科大学第一临床医学院心内科, 黑龙江 哈尔滨 150001）
Author(s):
SHAN Li-na;  YANG Wei
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
微小RNA; 心肌肥厚; 心血管疾病; 心力衰竭
Keywords:
miRNAs;  cardiac hypertrophy;  cardiovascular disease;  heart failure
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
心肌肥厚是心脏对损伤和压力负荷增加所做出的适应性反应，起初能代偿性的增加心脏输出做功，但持续性的心肌肥厚最终将导致心力衰竭甚至猝死。近年来众多研究发现非编码的小RNAs(microRNAs/miRNAs)在转录后水平调节相关蛋白的表达，参与了心肌肥厚的一系列病理生理过程。本文就与心肌肥厚相关的一系列miRNAs进行综述。
Abstract:
Cardiac hypertrophy is an adaptive response to pressure overload damage, which produces initial energy compensatory increase in cardiac output, but sustained cardiac hypertrophy will eventually lead to heart failure and even death. In recent years, numerous studies have found small non-coding RNAs (microRNAs/miRNAs) regulate the level of expression in post-transcriptional related proteins involved in cardiac hypertrophy series of pathophysiological processes. This article reviews a series of miRNAs associated with cardiac hypertrophy.

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备注/Memo

备注/Memo:
收稿日期：2014-10-15.
基金项目：国家自然科学基金项目资助(81271676)
通讯作者：杨巍，主任医师，主要从事冠脉介入和心衰发生机制研究 Email:hydyangwei@tom.com
作者简介：单丽娜，硕士生 Email：shanlina0643@163.com
更新日期/Last Update: 2015-04-28