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|本期目录/Table of Contents|

冠状动脉慢血流现象与血管内皮功能紊乱有相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
163-165,178
栏目:
临床研究
出版日期:
2015-11-25

文章信息/Info

Title:
Relationship between coronary slow flow and endothelial disorder
作者:
李祥廷1; 张少阳2; 邢 冰3; 武宗寅3
(1.济宁医学院附属医院心内科，山东 济宁 272000；
2.聊城市人民医院心内科，山东 聊城 252000；
3.济宁市第一人民医院心内科，山东 济宁 272000)
Author(s):
LI Xiang-ting1;  ZHANG Shao-yang2;  XING Bing3;  WU Zong-yin3
(1.Department of Cardiology, Affiliated Hospital of Jining Medical College, Jining 272000, Shandong, China；
2.Department of Cardiology, Liaocheng First People’s Hospital, Liaocheng 252000, Shandong, China；
3.Department of Cardiology, Jining First People’s Hospital, Jining 272000, Shandong, China)
关键词:
冠状动脉慢血流; 血管内皮功能
Keywords:
coronary slow flow;  vascular endothelial function
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨冠状动脉慢血流（CSF）现象与血管内皮功能的相关性。方法 选取2012年10月~2013年10月在济宁市第一人民医院心内科住院，经冠状动脉造影（CAG）证实为CSF且无冠状动脉狭窄、冠状动脉畸形及血栓形成的患者60例作为慢血流组，同时随机选取同期CAG证实血流正常且无冠状动脉狭窄、冠状动脉畸形及血栓形成的患者20例作为对照组。通过高分辨率多普勒超声仪测定两组患者的基础肱动脉内径（D0）、肱动脉内皮依赖血流量介导的舒张反应(FMD)及非内皮依赖的硝酸甘油介导的舒张反应（NID），以此反应两组患者的血管内皮功能。对慢血流组与对照组患者的性别、年龄、体质量指数（BMI）、吸烟比例、血脂、空腹血糖、血压、血管内皮功能指标进行组间比较和相关性分析。结果 慢血流组与对照组在年龄、BMI、空腹血糖、总胆固醇(TC）、三酰甘油(TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、舒张压水平等方面均无统计学差异；慢血流组吸烟比例（63% vs. 25%）、收缩压水平〔(126±12)mmHg vs.(119±13)mmHg〕均高于对照组（P<0.05）；慢血流组男性比例（78% vs. 30%）显著高于对照组（P<0.01）；慢血流组与对照组相比D0、NID无统计学差异；慢血流组FMD显著低于对照组〔(6.3±1.3)% vs.(10.2±1.9)%，P<0.01〕，其平均血流帧数与FMD呈明显负相关（r=-0.70，P<0.01）。结论 冠状动脉慢血流现象与内皮功能紊乱有相关性。
Abstract:
AIM To study the relationship between coronary slow flow (CSF) and endothelial disorder. METHODS Sixty CSF patients confirmed by coronary angiography (CAG) and determined by corrected TIMI frame count (CTFC) method and 20 patients with normal coronary angiography were assigned, respectively, to CSF group and control group (CNF group). Brachial artery diameter, brachial artery endothelium-dependent blood flow-mediated dilation response (FMD) and nitroglycerin-mediated nonendothelium-dependent relaxation response (NID) were measured by high-resolution Doppler ultrasound. Gender, age, body mass index (BMI), smoking rate, blood lipids, fasting blood glucose, blood pressure and endothelial function indicators were compared between groups. RESULTS No significant differences were found in age, BMI, fasting blood sugar, TC, TG, LDL-C, HDL-C, and diastolic blood pressure between groups. The proportion of smoking (63% vs. 25%) and systolic blood pressure ［(126±12) mmHg vs.(119±13) mmHg］ in CSF group was higher than those in the CNF group (P<0.05). The proportion of males in the CSF group was significantly higher than in the CNF group (78% vs. 30%, P<0.01). No significant differences in D0 and NID were found between groups. FMD in the CSF group was significantly lower than in control group ［(6.28±1.30)% vs.(10.2±1.9)%, P<0.01］ and the frame count of CSF group was negatively correlated with FMD (Pearson correlation coefficient, r=-0.70, P<0.01). CONCLUSION CSF is related to endothelial disorder, but other risk factors should also be taken into consideration.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2014-05-10.
通讯作者：武宗寅,主任医师，主要从事心脏电生理及介入研究 Email：wuzysp@163.com
作者简介：李祥廷，主治医师，硕士 Email：shinesunhi@126.com
共同第一作者：张少阳，住院医师，硕士 Email：360151676@qq.com
更新日期/Last Update: 2016-04-25