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慢性心力衰竭患者心肌HSP47表达及其与某些因素的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
160-162
栏目:
临床研究
出版日期:
2015-11-25

文章信息/Info

Title:
Expression of heat shock protein 47 and its correlation to some factors with chronic heart failure
作者:
田倪妮1; 2; 魏 玲1; 杨晓华1; 朱向情3; 阮光萍3; 陈 瑛2 ; 李宏键4
（成都军区昆明总医院:1.地方干部病房，3.云南省干细胞工程试验室，云南 昆明 650032；
2.昆明市第一人民医院心内科,云南 昆明 650011；
4.云南省第一人民医院骨科，云南 昆明 650034）
Author(s):
TIAN Ni-ni1; 2;  WEI Ling1;  YANG Xiao-hua1;  ZHU Xiang-qing3;  Ruan Guang-ping3;  CHEN Ying2;  LI Hong-jian4
(1.Wards for Civilian Cadres, 3.Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital, Chengdu Military Area Command, Kunming, 650032, Yunnan, China；
2.Cardiovascular Division, First People’s Hospital of Kunming, Kunming, 650011 Yunnan, 4.Department of Orthopedics, First People’s Hospital of Yunnan Province, Kunming 650011, Yunnan, China)
关键词:
热休克蛋白47; 心力衰竭; 慢性; 左室舒张末内径
Keywords:
heat shock protein 47;  heart failure;  chronic;  end-diastolic left ventricular diameter
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 探讨慢性心力衰竭患者心肌热休克蛋白47（HSP47）的表达及其与某些因素的相关性。方法 60例手术患者，采用实时荧光定量（RT-PCR）方法 检测心肌HSP47的mRNA表达量。结果HSP47mRNA在慢性心力衰竭患者中均有表达，且随心功能的下降HSP47表达升高。①慢性心力衰竭患者心肌HSP47与左室舒张末期内径呈独立、显著的正相关（r=0.785，P<0.05）,与左室射血分数呈负相关（r=-0.804,P<0.05）；②HSP47与年龄、血脂等无相关关系。结论 慢性心力衰竭患者心肌HSP47表达随心功能下降而升高，与左室舒张末期内径呈正相关，而与左室射血分数呈负相关。
Abstract:
AIM To investigate the correlation between heat shock protein 47 and some factors in chronic heart failure. METHODS Right atrial tissues were taken from 60 patients undergoing cardiac surgery. Twenty patients were in NYHA I group, 20 patients were in NYHA II group, and 20 patients were in NYHA III group. mRNA amounts of HSP47 were studied by real-time fluorescence quantitative PCR method. RESULTSHS P47mRNA was expressed in patients with chronic heart failure. There was a conspicuous and independent direct correlation between the expression of HSP47 and left ventricular diameter (r=0.785, P<0.05) and there was also an indirect correlation between the expression of HSP47 and EF. There was no correlation between the expression of HSP47 and ages, blood lipids and other factors in chronic heart failure. CONCLUSION In patients with chronic heart failure, heart function declined and expression of HSP47mRNA expression increased. Expression of HSP47 has a positive correlation with left ventricular diameter and a negative correlation with left ventricular ejection fraction.thromboembolism after RFCA.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-02-25.
基金项目：云南省基金课题资助（2010ZC175） 通讯简介：魏玲，主任医师，主要从事心血管和老年重症疾病研究 Email:weilling43@yahoo.com.cn
共同通讯作者：李宏键，副主任医师，主要从事老年运动系统疾病研究 Email:samhongjian@126.com
作者简介：田倪妮，主治医师，硕士生 Email：70326943@qq.com
更新日期/Last Update: 2016-04-25