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|本期目录/Table of Contents|

自噬与病毒性心肌炎关系研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第2期
页码:
221-225
栏目:
综述
出版日期:
2015-11-25

文章信息/Info

Title:
Research progress of relationship between autophagy and viral myocarditis
作者:
于建才; 赫嘉惠; 仲娇月; 赵德超
（哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨 150001）
Author(s):
YU Jian-cai;  HE Jia-hui;  ZHONG Jiao-yue;  ZHAO De-chao
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
自噬; 病毒性心肌炎; 氧化应激; 病毒感染
Keywords:
autophagy;  viral myocarditis;  oxidative stress;  coronavirus infections
分类号:
R452.2
DOI:
-
文献标识码:
A
摘要:
自噬（autophagy）是细胞依赖溶酶体对胞内蛋白质和受损细胞器进行降解的一条重要途径。细胞自噬受各种因子的精密调节，是细胞清除损伤物质和维持细胞稳态的重要调节方式，与心血管疾病、肿瘤和神经退行性疾病发生密切相关［1］。近几年有文献报道病毒性心肌炎中存在细胞自噬现象［2~4］，结合作者前期试验在小鼠病毒性心肌炎模型中亦观察到细胞自噬现象，因此本文就自噬与病毒性心肌炎的关系进行综述。
Abstract:
Autophagy is an important biological process in which the cytoplasmic constituents of protein and impaired organelles are sequestered in a double-membrane autophagosome and then delivered to the lysosome for degradation. Selective degradation of autophagy is highly regulated by various molecules. Autophagy is an important regulatory approach of clearing damaged cellular materials and maintaining cell homeostasis and is closely related to cardiovascular disease, tumors and neurodegenerative diseases. In recent years, there has been reported a phenomenon of autophagy in viral myocarditis. In our preliminary experiments of the mouse model of viral myocarditis, we also observed the phenomenon of autophagy. This review summarizes the research progress of the relationship between autophagy and viral myocarditis.

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备注/Memo

备注/Memo:
收稿日期：2015-01-24.
基金项目：黑龙江省自然科学基金资助（D201070）
通讯作者：赵德超，主任医师，主要从事病毒性心肌炎发病机制的研究 Email：drzhaodechao@163.com
作者简介：于建才，硕士生 Email：xiwangyjc@163.com
更新日期/Last Update: 2016-04-25