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|本期目录/Table of Contents|

KRT8、ANK1与冠心病的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第3期
页码:
296-298
栏目:
临床研究
出版日期:
2016-01-05

文章信息/Info

Title:
Correlation between KRT8, ANK1 and coronary heart disease
作者:
韦小未; 郭玲玉; 陈一竹; 周瑶瑶; 张明亮; 张俊峰; 王长谦
（上海交通大学医学院附属第三人民医院心内科，上海 201999）
Author(s):
WEI Xiao-wei;  GUO ling-yu;  CHEN Yi-zhu;  ZHOU Yao-yao;  ZHANG Ming-liang;  ZHANG Jun-feng;  WANG Chang-qian
(Department of Cardiology, Shanghai Third People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201999, China)
关键词:
冠状动脉疾病; 角蛋白; 锚蛋白; Gensini评分
Keywords:
coronary heart disease;  keratin;  ankyrin;  Gensini score
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 验证经内皮微粒蛋白组学筛选出的差异蛋白细胞角蛋白8（keratin8，KRT8）和锚蛋白1（Ankyrin 1，ANK1）与冠心病的相关性。方法 选择50例经冠脉造影证实的冠心病患者，以20例造影阴性患者为对照组，收集其外周静脉血，利用酶联免疫吸附实验检测KRT8、ANK1浓度，冠心病患者冠脉狭窄程度使用Gensini评分标准进行评分、分组。结果 KRT8、ANK1在冠心病患者中的浓度明显高于非冠心病组（P<0.05）；在冠心病亚组中，Gensini评分高分组与低分组之间KRT8、ANK1浓度差异对比分析，其均P<0.05，且ANK1、KRT8浓度差异与Gensini评分呈正相关。结论 KRT8、ANK1与冠心病有关联，且与冠状动脉病变严重程度呈正相关。
Abstract:
AIMTo explore the correlation between protein KRT8, ANK1 and coronary heart disease. METHODSWe recruited 50 patients confirmed by coronary angiography as having coronary heart disease, and 20 patients with negative coronary angiography results were assigned to control group. We performed enzyme immunosorbent assay to test the concentrations of KRT8 and ANK1 from the peripheral blood plasma of all subjects. Degrees of coronary stenosis in patients with coronary artery disease were scored using the standard of the Gensini score. RESULTSConcentrations of KRT8 and ANK1 in patients with coronary heart disease were significantly higher than those in the control group (P<0.05). Concentrations of KRT8 and ANK1 between high and low Gensini scores were significantly different in patients with coronary artery disease (P<0.05) and the concentration differences of ANK1 and KRT8 were positively correlated with Gensini scores. CONCLUSIONKRT8 and ANK1 are associated with coronary heart disease and are positively correlated with the severity of the lesions.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2015-03-02.
基金项目：上海申康市级医院适宜技术推广项目资助（SHDC12012210）；上海市宝山区科技发展基金 资助（12-E-63）
通讯作者：张俊峰，主任医师，主要从事冠心病综合防治研究 Email：jfzhang_dr@163.com
作者简介：韦小未，硕士生 Email：weixiaowei19902@163.com
更新日期/Last Update: 2016-01-07