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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2016年第4期

页码:

479-482,500

栏目:

综述

出版日期:

2016-04-01

文章信息/Info

Title:

Recent progress of pigment epithelium-derived factor in metabolic syndrome

作者:

张正斌¹; 邱光昊¹; 翟蒙恩²; 段维勋²; 刘金成²; 梁宏亮²

（第四军医大学:1.学员一旅九连，2.西京医院心血管外科，陕西 西安 710032）

Author(s):

ZHANG Zheng-bin¹;  QIU Guang-hao¹;  ZHAI Meng-en²;  DUAN Wei-xun²;  LIU Jin-cheng²;  LIANG Hong-liang²

(1.Ninth Company, First Brigade of Cadets, 2.Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)

关键词:

色素上皮衍生因子; 代谢综合征; 肥胖; 胰岛素抵抗

Keywords:

pigment epithelium-derived factor;  metabolic syndrome;  obesity;  insulin resistance

分类号:

R589

DOI:

-

文献标识码:

A

摘要:

代谢综合征（MS）是代谢层面的心血管危险因子的聚集现象，主要包括高血压、血脂异常、糖尿病、胰岛素抵抗及腹部肥胖等。近年来MS发病率明显上升并严重危害居民的身体健康。色素上皮细胞衍生因子(PEDF)属丝氨酸蛋白酶抑制基因家族，是由多种细胞表达，具有多种生物学活性的分泌性糖蛋白。近年来多项临床试验提示PEDF参与了MS的发生发展，是一个有希望的疾病治疗靶点。本文就PEDF在MS中的作用综述。

Abstract:

Metabolic syndrome (MetS) is a constellation of multiple metabolic risk factors including hypertension, dyslipidemia, glucose intolerance, insulin resistance and abdominal obesity. Over the past decades, the prevalence of MetS has increased dramatically, imposing a devastating and pandemic health threat. Pigment epithelium-derived factor (PEDF) is a multifunctional glycoprotein belonging to the superfamily of serine protease inhibitors produced from a variety of tissues. Cuulative studies have demonstrated that PEDF plays a pivotal role in the etiology of MetS. The present review focuses on the critical roles of PEDF in the development of MetS and the mechanisms behind them.

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备注/Memo

备注/Memo:

收稿日期：2015-03-20.
基金项目：国家自然科学基金项目资助（81200151，81200708)
通讯作者：梁宏亮，主治医师，主要从事缺血性心脏病研究 Email：dr.lianghongliang@hotmail.com
作者简介：张正斌，本科生 Email：zhengb_z@163.com

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更新日期/Last Update: 2016-04-01