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|本期目录/Table of Contents|

恩施土家族人群eNOS rs1799983基因多态性和肥胖在原发性高血压中的交互作用

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2016年第6期
页码:
690-693
栏目:
临床研究
出版日期:
2016-07-05

文章信息/Info

Title:
Interaction between obesity and eNOS polymorphism in hypertension in Tujia population
作者:
华晓芳; 朱小琴; 黄 浩;  张复贵
（恩施土家族苗族自治州中心医院心血管科，湖北 恩施 445000）
Author(s):
HUA Xiao-fang;  ZHU Xiao-qin;  HUANG Hao;  ZHANG Fu-gui
(Department of Cardiovascular Disease, Central Hospital, Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, Hubei, China)
关键词:
rs1799983; 多态性; 原发性高血压; 易感性; 交互作用
Keywords:
eNOS;  polymorphism;  hypertension;  susceptibility;  interaction effects
分类号:
R541.3
DOI:
-
文献标识码:
A
摘要:
目的 探讨恩施土家族人群内皮型一氧化氮合酶(eNOS)rs1799983多态性与原发性高血压(EH)关联性及其与肥胖交互作用。方法 采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)方法分析127例EH患者和127名正常对照eNOS rs1799983基因型。非条件Logistic分析各基因型与发病中易感性关系以及与肥胖的交互作用。结果 携带C(CC/CT)基因个体患病风险较非C基因携带者(TT)风险明显增加1.35倍(OR=1.35,95%CI: 1.22,2.56,P<0.01;校正OR=1.61,95%CI: 1.21,3.01,P<0.01);非条件Logistic分析表明携带CC/CT基因型肥胖个体EH罹患风险是携带TT基因非肥胖个体的3.39倍(OR=3.39,95%CI:2.66,5.36,P=0.000)(RERI=1.94,95%CI:1.41,2.77;API=0.59,95%CI:0.33,0.84;S=1.46,95%CI:1.37,2.66)。结论 eNOS rs1799983多态性增加恩施土家族个体原发性高血压罹患风险,且与肥胖存在原发性高血压发病中存在协同效应。
Abstract:
AIM To study the relationship between rs1799983 polymorphism in endothelial nitric oxide synthase (eNOS) and susceptibility to hypertension and its interaction with obesity in Tujia population. METHODSGenotypes of 120 patients with hypertension and 140 control subjects were examined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Unconditional logistic regression (ULR) was performed to assess hypertension risk and interaction with obesity. RESULTSA case-control analysis indicated that there was a higher risk of developing hypertension in CC/CT genotype carriers than in TT genotype carriers (OR=1.35, 95%CI: 1.22, 2.56, P=0.000; adjusted OR=1.61, 95%CI: 1.21, 3.01, P=0.000). By ULR method, obesity-positive subjects with genotype CT/CC had a hypertension risk 3.39 times higher than obesity-negative subjects with genotype TT (OR=3.39, 95%CI: 2.66, 5.36, P=0.000) (RERI=1.94, 95%CI: 1.41, 2.77; API=0.59, 95%CI: 0.33, 0.84; S=1.46, 95%CI: 1.37, 2.66). CONCLUSIONeNOS rs1799983 polymorphism is associated with increased risk for hypertension in Tujia population with a synergistic interaction.

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备注/Memo

备注/Memo:
收稿日期：2015-10-08.
基金项目：湖北省自然科学基金项目资助(2013DC141)
通讯作者：张复贵，主任医生，主要从事心血管发病机制研究Email:zhangfugui234@sinca.com
作者简介：华晓芳，主治医生Email:huaxiaofang@sinca.com
更新日期/Last Update: 2016-07-10