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|本期目录/Table of Contents|

血管内皮细胞线粒体动力学相关功能与心血管疾病关系的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第1期
页码:
105-108
栏目:
综述
出版日期:
2016-10-05

文章信息/Info

Title:
Research progress of the relationship between vascular endothelial cell mitochondria dynamic-related functions and cardiovascular disease
作者:
高 磊; 张 欣; 刘 越 综述; 尹新华 审校
（哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨 150001）
Author(s):
GAO Lei;  ZHANG Xin;  LIU Yue;  YIN Xin-hua
(Department of Cardiology, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
血管内皮细胞; 线粒体动力学; 线粒体自噬; 线粒体-内质网结构偶联; 心血管疾病
Keywords:
vascular endothelial cells;  mitochondrial dynamics;  mitophagy;  mitochondria-endoplasmic reticulum physical coupling;  cardiovascular disease
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
细胞线粒体动力学相关功能是指线粒体通过不断地融合与分裂、线粒体自噬及线粒体-内质网结构偶联来维持细胞正常生理功能的过程。其异常与神经退行性病变、肿瘤、视神经萎缩及糖尿病等疾病的发生发展关系密切。近年来，血管内皮细胞（vascular endothelial cell，VEC）线粒体相关功能在心血管疾病中的研究受到广泛关注，研究发现VEC线粒体相关功能异常在心肌缺血/再灌注（I/R）损伤、冠状动脉粥样硬化、肺动脉高压及扩张型心肌病等疾病的发生发展中发挥重要作用。本文就VEC线粒体动力学相关功能及与心血管疾病的关系进行简要阐述。
Abstract:
Mitochondrial dynamic-related function is the process of maintaining normal physiological cell function by continuous fusion and fission, mitochondrial autophagy and mitochondria-endoplasmic reticulum physical coupling. Its abnormal function is closely related to the development of neurodegenerative diseases, tumors, optic nerve atrophy and diabetes. In recent years, studies of vascular endothelial cell (VEC) mitochondrial-related functions in cardiovascular disease have received extensive attention. Studies have found that the abnormal function of VEC mitochondrial dynamic-related functions play an important role in the occurrence and development of cardiac ischemia reperfusion injury, coronary atherosclerosis, pulmonary hypertension, dilated cardiomyopathy and hypertension. In this paper, the relationship between VEC mitochondrial dynamic-related functions and cardiovascular diseases is described.

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备注/Memo

备注/Memo:
收稿日期：2015-09-16.基金项目：国家自然科学基金项目资助（81570437；81200235）
通讯作者：尹新华，教授，主要从事冠心病和心力衰竭研究 Email:xinhua_yin@163.com
作者简介：高磊，硕士生 Email:gaolei_yida@126.com
更新日期/Last Update: 2016-10-09