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不同剂量参附注射液联合左卡尼汀治疗老年慢性心力衰竭的疗效观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第3期
页码:
313-316
栏目:
临床研究
出版日期:
2017-01-25

文章信息/Info

Title:
Efficacy of large doses of shenfu injection combined with levocarnitine in elderly patients with chronic heart failure
作者:
曹学敏1; 张 菁2; 龙升华1
鄂东医疗集团黄石市中心医院、湖北理工学院附属医院：1.心内科，2.呼吸内科，湖北 黄石 435000
Author(s):
CAO Xue-min1;  ZHANG Jing2;  LONG Sheng-hua1
1.Department of Cardiology, 2.Department of Respiration, Huangshi Central Hospital & Affiliated Hospital of Hubei Polytechnic University, Huangshi 435000, Hubei, China
关键词:
参附注射液; 左卡尼汀; 老年人; 慢性心力衰竭; 心功能评价
Keywords:
shenfu injection;  levocarnitine;  elderly;  chronic heart failure;  heart function evaluation
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 对比分析不同剂量参附注射液联合左卡尼汀治疗老年慢性心力衰竭(CHF)的疗效差异。方法 选择于2014年3月~2015年12月在入住本院的老年CHF患者142例，随机分为参附50 ml组（47例）、参附100 ml组（48例）和对照组（47例）。所有患者均接受常规抗心衰药物治疗及左卡尼汀2 g/d，参附50 ml组再给予参附注射液50 ml/d,参附100 ml组给予参附注射液100 ml/d，14 d为1个疗程。比较3组治疗前及治疗后的NYHA心功能分级和Lee氏心衰积分、心功能、血N末端脑钠肽前体(NT-proBNP)、生活质量评分及6分钟步行试验（6MWT）的差异。结果 参附100 ml组患者的NYHA心功能分级、Lee氏心衰积分、左室射血分数、心肌做功指数、NT-proBNP、生存治疗和6MWT改善较另外两组患者的更显著（P<0.05）；参附100 ml组的临床显效率及总有效率也高于另外两组。结论 对于老年CHF患者，参附注射液联合左卡尼汀疗效确切，大剂量参附注射液联合左卡尼汀疗效更好。
Abstract:
AIM To compare and analyze the clinical efficacy and safety of large doses of shenfu injection combined with levocarnitine in elderly patients with chronic heart failure. METHODS One hundred and forty-two patients from March 2014 to December 2015 were randomly divided into three groups: observation group A (n=47), observation group B (n=48) and control group (n=47). In addition to conventional therapy and levocarnitine 2 g/day for all patients, patients in observation group A were given shenfu injection (50 ml/day) and patients in observation group B were given shenfu injection (100 ml/day). NYHA (New York Heart Association) Functional Classification, Lee’s heart failure scores, left ventricular ejection fractions (LVEF), myocardial performance index (MPI), NT-proBNP, quality of life score and 6-min walk test (6 MWT) before and after treatment in the three groups were compared. RESULTS A significant improvement in the NYHA, Lee's heart failure scores, LVEF, MPI, NT-proBNP, quality of life score and 6 MWT was seen in observation group B compared with those in the other two groups (P<0.05). Treatment efficiency and total effective rate in observation group B were also higher than those in the other two groups (P<0.05). CONCLUSION Shenfu injection combined with levocarnitine shows a definite therapeutic effect in elderly patients with chronic heart failure and a large dose (100 ml/day) of shenfu injection combined with levocarnitine achieves obviously better curative effect than the lower dose (50 ml/day).

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备注/Memo

备注/Memo:
收稿日期：2016-03-16.通讯作者：张菁，主管护师，主要从事老年麻醉学研究 Email:phage79@163.com 作者简介：曹学敏，主治医生 Email：718121448@qq.com
更新日期/Last Update: 2017-02-20