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|本期目录/Table of Contents|

LncRNA与miRNA在动脉粥样硬化中互相作用的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2018年第1期
页码:
92-094,098
栏目:
综述
出版日期:
2017-10-10

文章信息/Info

Title:
Research progress in interactions between lncRNA and miRNA in atherosclerosis
作者:
郑 阳; 李 爽; 张寒璐; 张毛毛; 孙 勇; 于 波; 吴 健
（哈尔滨医科大学附属第二医院心内科，黑龙江 哈尔滨 150001）
Author(s):
ZHENG Yang;  LI Shuang;  ZHANG Han-lu;  ZHANG Mao-mao;  SUN Yong;  YU Bo;  WU Jian
(Department of Cardiology, Second Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China)
关键词:
长链非编码RNA; microRNA; ceRNA; 动脉粥样硬化
Keywords:
long non-coding RNA;  microRNA;  competing endogenous RNA;  atherosclerosis
分类号:
R543.5
DOI:
-
文献标识码:
A
摘要:
最近研究发现非编码RNA在生物学过程中参与重要作用，包括细胞的增殖、分化、迁移和肿瘤的发生等，在动脉粥样硬化（AS）中也发挥重要作用。长链非编码RNA（lncRNA）和miRNA之间的互相作用能够更好体现复杂的生物学网络调控，成为治疗疾病的新靶点。而lncRNA和miRNA相互作用的研究在AS中处于初始阶段，具体机制尚不明确。本文综述了在AS中lncRNA和miRNA之间相互作用的研究进展。
Abstract:
Recent research has demonstrated that non-coding RNA play an important role in bioprocess, including cell proliferation, differentiation, migration and tumorigenesis. It has significant effects on atherosclerosis. The interaction between lncRNA and miRNA can reflect complicated biological networks and provides new therapeutic targets. At this time, the mechanism of mediation or modulation of the interaction between lncRNA and miRNA is in early stages and the precise mechanism is not clear. This article reviews the research progress in interaction between lncRNA and miRNA in atherosclerosis.

参考文献/References

[1]Libby P,Bornfeldt KE,Tall AR.Atherosclerosis:Successes,Surprises,and Future Challenges[J].Circ Res,2016,118(4):531-534.

[2]Nabel EG,Braunwald E.A tale of coronary artery disease and myocardial infarction[J].N Engl J Med,2012,366(1):54-63.

[3]Uchida S,Dimmeler S.Long noncoding RNAs in cardiovascular diseases[J].Circ Res,2015,116(4):737-750.

[4]Thum T,Condorelli G.Long noncoding RNAs and microRNAs in cardiovascular pathophysiology[J].Circ Res,2015,116(4):751-762.

[5]Bartel DP.MicroRNAs:genomics,biogenesis,mechanism, and function[J].Cell,2004,116(2):281-297.

[6]Kapranov P,Cheng J,Dike S,et al.RNA maps reveal new RNA classes and a possible function for pervasive transcription[J].Science,2007,316(5830):1484-1488.

[7]Engreitz JM,Pandya-Jones A,McDonel P,et al.The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome[J].Science,2013,341(6147):1237973.

[8]Gimbrone MA,Jr.,Garcia-Cardena G.Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis[J].Circ Res,2016,118(4):620-636.

[9]Shan K,Jiang Q,Wang XQ,et al.Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction[J].Cell Death Dis,2016,7(6):e2248.

[10]Lu W,Huang SY,Su L,et al.Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells[J].Sci Rep,2016,6:21620.

[11]Tang Y,Jin X,Xiang Y,et al.The lncRNA MALAT1 protects the endothelium against ox-LDL-induced dysfunction via upregulating the expression of the miR-22-3p target genes CXCR2 and AKT[J].FEBS Lett,2015,589(20 Pt B):3189-3196.

[12]He C,Ding JW,Li S,et al.The Role of Long Intergenic Noncoding RNA p21 in Vascular Endothelial Cells[J].DNA Cell Biol,2015,34(11):677-683.

[13]Bianchessi V,Badi I,Bertolotti M,et al.The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells[J].J Mol Cell Cardiol,2015,81:62-70.

[14]Majesky MW.Vascular Smooth Muscle Cells[J].Arterioscler Thromb Vasc Biol,2016,36(10):e82-e86.

[15]Gao W,Zhu M,Wang H,et al.Association of polymorphisms in long non-coding RNA H19 with coronary artery disease risk in a Chinese population[J].Mutat Res,2015,772: 15-22.

[16]Bao MH,Feng X,Zhang YW,et al.Let-7 in cardiovascular diseases,heart development and cardiovascular differentiation from stem cells[J].Int J Mol Sci,2013,14(11):23086-23102.

[17]Leung A,Trac C,Jin W,et al.Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells[J].Circ Res,2013,113(3):266-278.

[18]Moore KJ,Sheedy FJ,Fisher EA.Macrophages in atherosclerosis:a dynamic balance[J].Nat Rev Immunol,2013,13(10):709-721.

[19]Hu YW,Zhao JY,Li SF,et al.RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction[J].Arterioscler Thromb Vasc Biol,2015,35(1):87-101.

[20]Chen MT,Lin HS,Shen C,et al.PU.1-Regulated Long Noncoding RNA lnc-MC Controls Human Monocyte/Macrophage Differentiation through Interaction with MicroRNA 199a-5p[J].Mol Cell Biol,2015,35(18):3212-3224.

[21]Tall AR,Yvan-Charvet L.Cholesterol, inflammation and innate immunity[J].Nat Rev Immunol,2015,15(2):104-116.

[22]Cui M,Xiao Z,Wang Y,et al.Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway[J].Cancer Res,2015,75(5):846-857.

备注/Memo

备注/Memo:
收稿日期：2016-10-18.通讯作者：吴健，教授，主要从事心血管疾病研究 Email：wujian780805@163.com 作者简介：郑阳，硕士生 Email：zhengyanghmu@163.com
更新日期/Last Update: 1900-01-01