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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2018年第3期

页码:

278-281,288

栏目:

临床研究

出版日期:

2018-03-25

文章信息/Info

Title:

The clinical study of coronary artery lesion characteristic, clinical feature and risk factor in Uygur and Han elderly patients with acute coronary syndrome

作者:

依力哈木·阿不力提甫¹; 古孜丽²; 李国庆²; 穆叶赛·尼加提¹; 2

(1.新疆医科大学研究生学院，2.新疆维吾尔自治区人民医院心内科，新疆 乌鲁木齐 830000)

Author(s):

Yilihamu·Abulitifu¹;  GU zi-li²;  LI Guo-qing²;  Muyesai·Nijiati¹; 2

(1.Graduate School, Xinjiang Medical University, Urumqi 830000, Xinjiang, China; 2.Department of Cardiology, People’s Hospital of Xinjiang Uygur Autonomous Region , Urumqi 830000, Xinjiang, China)

关键词:

维吾尔族; 汉族; 老年; 急性冠脉综合征; 冠状动脉病变特点; 危险因素

Keywords:

uygur and han elderly;  acute coronary syndrome;  characteristics of coronary artery lesions;  risk factors

分类号:

R541.4

DOI:

-

文献标识码:

A

摘要:

目的 探讨维吾尔族与汉族老年急性冠脉综合征(ACS)患者的临床特征和冠状动脉病变特点以及维吾尔族老年ACS冠脉C型病变的危险因素。方法 回顾性分析330例在我院诊断考虑ACS并行冠脉造影的年龄≥65岁的维吾尔族与汉族患者临床资料、脂蛋白（Lp）α、血清尿酸（UA）、胱抑素（Cystatin，Cys）C、视黄醇结合蛋白（retinol binding protein，RBP）4、纤维蛋白原(FG)等生化指标。根据冠状动脉造影结果冠状动脉病变特点由冠状动脉血管优势分型、病变血管支数、病变累及血管、血管病变分型、Gensini积分表示。根据民族分为维吾尔族老年ACS组（154例）和汉族老年ACS组（176例）。根据冠脉造影结果将维吾尔族老年ACS患者分为冠状动脉C型病变组（99例）与冠状动脉非C型病变组（55例），分析影响维吾尔族冠状动脉C型病变的危险因素。结果 维吾尔族老年ACS组冠状动脉C型病变比例、Gensini积分明显高于汉族老年ACS组，差异有统计学意义（P<0.05）。维吾尔族老年ACS患者冠状动脉C型病变相关的危险因素依次为高血压病（OR=4.324）、高脂血症（OR=3.732）、FG（OR=1.827）、UA（OR=1.006）、Lpα（OR=1.003），均P<0.05。结论 维吾尔族老年ACS患者冠脉病变特点与汉族老年ACS患者相比，存在民族差异。维吾尔族老年ACS患者冠状动脉C型病变发生率较高，冠状动脉病变程度较汉族老年ACS患者严重。高血压病、高脂血症、FG、UA和Lpα是维吾尔族老年ACS患者冠脉C型病变的危险因素。

Abstract:

AIM To investigate the characteristics of coronary artery lesion, clinical feature in elderly patients with acute coronary syndromes (ACS) of Uygur and Han nationality, and risk factors of Uygur elderly patients with coronary artery C type lesions. METHODS Retrospective analysis of 330 hospitalized patients with a diagnosis of ACS combined with coronary angiography ages≥65 years old; Uygur and Han patients basic data, Lipoprotein a (Lpa), Serum uric acid (UA), Cystatin C (CysC), Retinol binding protein 4 (RBP4), Fibrinogen (FG) and other biochemical indicators. According to the results of coronary angiography coronary artery lesions characterized by coronary artery superiority classification, pathological vascular count, vascular lesions, vascular disease classification, and Gensini points. The subjects were divided into Uygur elderly ACS group (154 cases) and Han elderly ACS group (176 cases). According to the results of coronary angiography in elderly patients with ACS were divided into Uygur elderly patients with ACS type C coronary disease group (99 cases) and Uygur elderly patients with ACS non type C lesion group (55 cases), analyze the risk factors of Uygur with coronary artery C type lesion. RESULTS The coronary artery C type lesion and Gensini score in the Uygur group were significantly higher than that in the Han nationality group (P<0.05). The risk factors of coronary artery C type lesions in Uygur elderly patients with ACS were Hypertension (OR=4.324), Hyperlipidemia (OR=3.732), Fibrinogen (OR=1.827), Uric acid (OR=1.006), Lipoprotein a (OR=1.003), P<0.05. CONCLUSION There were national differences in risk factors among Uygur and Han elderly patients with ACS. The incidence rate of C type lesions in Uygur elderly acute coronary syndrome patients is higher and the degree of coronary lesions were more serious than that of the older Han patients. Hypertension, Hyperlipidemia, Fibrinogen, Lipoprotein a and Uric acid are risk factors for the coronary artery C type lesion in Uygur elderly patients with ACS.

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备注/Memo

备注/Memo:

收稿日期：2017-10-31.基金项目：国家自然科学基金项目资助(81160029),新疆维吾尔自治区自然科学基金项目资助(2015211C194) 通讯作者：穆叶赛·尼加提，教授，主要从事急性冠脉综合征研究 Email：muyassar11@aliyun.com 作者简介：依力哈木·阿不力提甫，硕士生 Email：421009928@qq.com

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更新日期/Last Update: 1900-01-01