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|本期目录/Table of Contents|

降钙素基因相关肽对犬冠脉流量及冠状动脉的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1994年第2期
页码:
76-78
栏目:
论著
出版日期:
1994-03-01

文章信息/Info

Title:
Effects of calcitonin gene-related peptide on canine coronary blood flow and coronary arteries
作者:
牛国保1 李红梅2 李金玲3 裴建明1 臧益民1 朱妙章1 施溥涛4
第四军医大学生理学教研室 西安 710032 2解放军第323医院心内科 3兰州军医学校生理学教研室 4上海生物化学研究所
Author(s):
Niu Guobao1; Li Hongmei2; Li Jinling3; Pei Jianming1; Zang Yimin1; Zhu Miaozhang1 and Shi Putao4
1Department of Physiology，Fourth Military Medical University，Xi’an 710032 2Department of Cardiology，Hospital 323 of Chinese PLA 3Department of Physiology，Military Medical School of Lanzhou 4Shanghai Institute of Biochemistry
关键词:
肽; 降钙素基因相关肽; 心肌缺血; 冠脉流量; 冠状动脉; 离体; 狗
Keywords:
calcitonin gene-related peptide; myocardial ischemia;  isolated coronary artery; coronary blood flow; dogs
分类号:
-
DOI:
-
文献标识码:
-
摘要:
本研究通过整体及离体灌流实验观察到重度冠脉狭窄时，犬冠脉流量(CBF),平均动脉压(MAP)明显减小，而心率(HR)则增加。狭窄30 min后由冠状动脉注射降钙素基因相关肽(CGRP)0.3 μg／kg后,CBF、MAP和HR可恢复正常水平。同时，缺血犬的离体冠状动脉对CGRP的反应也出现改变。大冠脉舒张反应明显降低；而小冠脉的舒张反应与正常相比，无明显改变，这可能与缺血后大冠脉的内皮细胞容易损伤有关。同时也提示：急性心肌缺血时，冠脉流量的减少，主要由于小冠状动脉收缩所致。
Abstract:
In the present study，it was observed that coronary blood flow(CBF)and mean blood pressure(MAP)decreased significantly with increased heart rate(HR)in severe coronary stenosis． Foliowing intracronary injectien of 0.3 μg／kg CGRP 30 min after stenosls CBF,MAP and HR recovered to normal．In isolated coronary arteries of dogs with myocardial ischemia，response to CGRP was changed．The relaxation effect of large artery markedly decreased，while that of small one had no significant change compared with that of controls,which may be related to endothelium injury of large coronary artery following myocardial ischemia，The results also，suggested that decrease of CBF was mainly due to contraction of small coronary artery．

参考文献/References

［1］Resenfeld MC，Mermod TJ，Amara SG，et al.Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing．Nature 1983；304：129.

［2］ Skofitich C，Jacobowitz DM．Quantitative distribution of Calcitoningene-re1ated peptide in rat control nervous system.Peptides 1985；6：1069.

［3］Mulderry PK，Ghatei MA，Rodrigo J，et a1. Calcitonin gen-related peptide in cardiovascular tissues of the rat．Neuroscience 1985：14：947.

［4］Holman JJ,et al.Human α-CGRP and rat α-CGRP are coronary vasodilators in the ret.Peptides 1986：7：23.

［5］孙建中,李之源,臧益民,朱妙章,等.急性心肌缺血时对犬冠状血管反应的影响．中华医学杂志 1986；66：13.

［6］陈士良，臧益民，朱妙章，等．冠状动脉狭窄对血流量的影响．生理学报 1989；41(4)：91.

备注/Memo

备注/Memo:
Received 1993-08-31
更新日期/Last Update: 1994-03-01