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|本期目录/Table of Contents|

乙酰胆碱对犬冠状动脉循环和心电活动的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1994年第2期
页码:
79-83
栏目:
论著
出版日期:
1994-03-01

文章信息/Info

Title:
Effects of acetylcholineon coronary circulation and electrocardiac activity in dogs
作者:
马茂儒1 贾国良2 李兰荪2 陈士良2 胡三觉3
1兰州军区乌鲁木齐总医院心内科 乌鲁木齐 830000 2第四军医大学西京医院心内科 3第四军医大学生理学教研室
Author(s):
Ma Maoru1; Jia Guoliang2; Li Lansun2; Chen shiliang2; and Hu Sanjue3
1Department of Cardiology，General Hospital of Lanzhou Military Command，Urumuqi，Xinjiang 2Xijing Hospital 3Department of Physiology，Fourth Military Medical University，Xian 710032
关键词:
乙酰胆碱; 狗; 心电描记法; 血液灌注; 冠状动脉; 冠状动脉血流量
Keywords:
acetylcholine; doys; electrocardiography; coronary hemo perfusion：coronary artery; coronary blood flow
分类号:
-
DOI:
-
文献标识码:
-
摘要:
本研究对22条犬，在建立颈总动脉向左冠脉回旋支(LCX)供血的模型基础上，进行刺激右侧迷走神经(RV)．LCX内注射乙酰胆硷(Ach)、硝酸甘油(NG)、去甲肾上腺素(NE)等买验，观察冠脉灌注压(CPP)、冠脉平均血流量(CBF)及ECG的变化。结果表明：刺激RV和冠脉(CA)内注射Ach对心脏频率、传导和心肌收缩力的押制作用，随刺激强度和注射剂量的增加而加强；小剂量NG可直接扩张CA，使CBF增加，大剂量Ach可能诱发CA痉挛和严重心律失常，并使CPP和CBF降低。
Abstract:
The effects of acetylcholine on coronary circulation and electrocardiac activity were observed using an animal model of supplying blood from common carotid artery to circureflex branch of left coronary artery in 22 dogs．Right vagus nerve stimulation and intracoronary injection of acetylcholine exerted inhibitory effect on heart rate，cardiac conductivity and contractility,which was intensity-and dose-dependent．Small dosage of nitroglycerin caused dilation of coronary artery Acetylcholine,at large dose, may induce coronary artery spasm and severe arrhythmia，and decrease coronary perfusion pressure and coronary blood flow．

参考文献/References

［1］Furchgott RF，Zawadzki JV．The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine．Nnture 1980：288：373.

［2］Greeenberg SS，Wilcox DE，Rubanyi GM．Endothelium-derived relaxing factor released from canine femoral artery by acetylcholine cannot be identified ag free nitric oxide by electron paramagnetic resonance spectroscopy．circ Res 1990;67：1446.

［3］Vita JA，Treasurs CB．Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease． Circulation 1990：81(2)：491.

［4］Vrints JM,Bult H,Hittre E,et a1.Impaired ondothelium-dependent cholinergic coronary vasodilation in patients with angina and normal coronary arteriograms.J Am Coll Cmardiol 1992;19(1)：21.

［5］杨均国，等．心律失常的近代概念．上海：上海科学技术出版社，1990：5～134.

［6］臧伟进，臧益民．心脏对乙酰胆碱的脱敏现象．心功能杂志 1993；5(4)：284.

［7］朱妙章，碱益民．迷走神经对心脏的兴奋作用及其产生原理．见：臧益民 朱妙章，主编．临床心血警生理学及其进展．北京：世界图书出版公司，1993：65～70.

[8]Kawamura A，Fujiwara H，Onodera T,et a1.Response of large and small coronary arteries of pigs to intracoronary injection of injecting acetylcholine angiographic and histologic analysis．Intern J Cardiol 1989；25(3)：289.

［9］陈士良，等．硝基甘油对狗缺血区冠脉循环的作用．药学学报 1990；25(10)：721.

备注/Memo

备注/Memo:
Received 1993-11-10
更新日期/Last Update: 1994-03-01