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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

1994年第3期

页码:

139-141,148

栏目:

论著

出版日期:

1994-05-01

文章信息/Info

Title:

Hypotensive effect of hexametazidine in rats and its mechanism

作者:

徐礼鲜¹ 赵德化² 刘亚南³

笫四军医大学 1口腔医学院麻醉科 2药理学教研室 西安710032 3西北国棉三厂职工医院内科

Author(s):

Xu Lixian1; Zhao Dehua2; Liu Yanan3

1Department of Anesthesiology，Stomatological Hospital，2Department of Pharm acology，Fourth Military Medical University.3Department of Interna1 Medicine，Staff Hospita1，The third Cotton Mill in Northwest China,Xi’an 710032

关键词:

六甲氧苄嗪; 三甲氧苄嗪; 血压测定; 大鼠

Keywords:

hexametazidine; trimetazidine; blood pressure determination：rats

分类号:

-

DOI:

-

文献标识码:

-

摘要:

本文用动脉插管直接测压的方法，研究了六甲氧苄嗪(HMZ)对麻醉大鼠正常血压的影响。结果表明，HMZ能降低血压，以降低舒张压和平均压为主，且能部份对抗去甲肾上腺素的升压作用，同时与异丙肾上腺素合用时似有协同作用。初步认为HMZ的降压效应与α受体和β受体无明显关系，可能与抑制Ca²⁺通道有关。

Abstract:

We studied the action of hexametazidine(HMZ)on norma1 blood pressure in anesthetized rats．The results indicated that HMZ could decrease blood pressure and total peripheral resistance;in addituon it attenuated theh hypertensive effect of noradrenaline and was cooperative action with isoetharine in reducing blood pressure.These findings indicated that HMZ was neither a α-adrenoceptor blocking agent nor a β-adrenoceptor exciting agent,suggesting that calcium channel b1ocking mechanism may be involved in action of HMz.

参考文献/References

［1］徐礼鲜，李玉清，赵德化.六甲氧苄嗪对豚鼠离体主动脉的扩张作用．第四军医大学学报 1993；13(4)：287.

［2］Jia YS，Zhao DH，Sheng BH．Effects of hexametazidine on physiological properties of guinea-pig papillary muscles．J Med Coll PLA 199l；6(2)：17O .

［3］Garnier D，Roulet MJ.Vasoactivity of trimetazidine on guinea-pig isolated ductus arteriosus．J Phormocol 1985;84(2):517.

［4］Toda N，Usui H，Osumi S，et al.Influence of trimetazidine,an antianginal drug on isolated dog arteries and veins．Pharmocodyn Ther 1982：260(2)：230.

备注/Memo

备注/Memo:

received 1993-05-l8：revised 1994-01-14

常用功能

更新日期/Last Update: 1994-05-01