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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

1994年第3期

页码:

136-138

栏目:

论著

出版日期:

1994-05-01

文章信息/Info

Title:

Changes and significance of cyclonucleotide in plasma with congestive heart failture

作者:

李科民¹ 迮祖光¹ 崔普坤¹谢 冉² 江秉钧²

蚌埠市第一医院 1心内科 2放免室 蚌埠 233000

Author(s):

Li Kemin; Za Zuguang; Cui Pukun; Xie Ran and Jiang Bingjun

Department of Cardiovascular Diseases，Bengbu First People’s Hospital，Anhui 233000

关键词:

环-磷酸腺苷; 环-磷酸乌苷; 心力衰竭; 充血性; 心脏功能试验; 放射免疫测定

Keywords:

adenosine cyclic-3’5’-monophosphate; guanosine cyclic-3’5’monophosphate：heart failure; congestive; heart function tests; radioimmunoassay

分类号:

-

DOI:

-

文献标识码:

-

摘要:

本文应用放射免疫分析方法研究充血性心衰患者血浆环核苷酸(cAMP，cGMP)水平．发现随心衰程度加重，cAMP、cGMP值增加。cAMP／cGMP值减小，与正常人有显著差异。心衰纠正后，cAMP、cGMP值下降，cAMP／cGM P值增加．与治疗前比，有显著差异。由此可见，血浆中环核苷酸水平可作为衡量心功能的一个指标。

Abstract:

This paper reports the level of cyclonuc1eotide in plasma of patients with congestive heart failure with radioimmunoassay plasma cAMP,cGMP levels was found increased with deterioration of heart failure whereas cAMP，cGMP ratio decreased，which are remarkably different from those of healthy peop1e.After heart failure control，cAMP，cGMP level decreased，whereas cAMP，cGMP ratio increasd．There was a remarkable difference between those of the group before treatment and those of the group after treament．Therefore，plasma cyclonucletide level maybe consider as an lndex of cardlac function.

参考文献/References

［1］陈 修，主编．心血管药理学．北京：人民卫生出版社，1986：89.

［2］Nobiari F，et a1．J Lab Clin Med 1987：109：7063.

［3］郑 兴，等．中华心血管病杂志 1987：17(4)：213.

［4］冯新为，主编．病理生理学．第二版．北京：人民卫生出版社，1985：140.

[5]宋喜秀,等．临床肝胆杂志 1988；4(4)：50.

［6］赵玉书，等．临床荟萃 1991；6(9)：414.

备注/Memo

备注/Memo:

received 1992-O6-17

常用功能

更新日期/Last Update: 1994-05-01