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|本期目录/Table of Contents|

降钙素基因相关肽的血液动力学作用及其机理(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1995年第1期
页码:
13-16
栏目:
论著
出版日期:
1995-01-01

文章信息/Info

Title:
Hemodynamic effect and its mechanism of action of calcitonin gene-related peptide in rats
作者:
李红梅1 裴建明1 朱妙章1 牛国保1 臧益民1 李金铃2 张宁仔3 施溥涛4
1第四军医大学生理学教研室 西安 710032 2兰州军区军医学校 3唐都医院心内科 4上海生物化学研究所
Author(s):
Li Hongmei; Pei Jianming; Zhu Miaozhang; et al
Department of Physiologr,Fourth Military Medical University,Xian 710032
关键词:
降钙素基因相关肽; 血液动力学; 自主神经系统
Keywords:
calcitonin gene-related peptide; hemodynamics; autonomic nervous system
分类号:
-
DOI:
-
文献标识码:
-
摘要:
静脉注射降钙素基因相关肽(CGRP)，可使麻醉大鼠血压明显下降，在注射后1 min出现作用．5 min最明显(平均动脉压下降15.5％)．10 min后恢复。在用荮后心率最快时增加9.4％，持续30 min．左室收缩压峰值和左室压上升最大速度分别增加10％和15％。CGRP的降压作用不能被阿托品阻断，且心率加快，心肌收缩性增强。预先用利血平阻断交感神经后再注射CGRP，心率无变化，平均动脉压、左室收缩压峰值、左室压上升最大速度均显著降低，且作用持续时问长。结果表明，CGRP的作用与交感神经的调控有密切关系．它的正性变力和变时的作用可能是通过交感神经释放递质引起的。
Abstract:
Intravenous injection of CGRP produced a fall of blood pressure within 1 min,the maximum change occurred at about 5 min and recovered in 10 min.Heart rate increased by 9.4％and lasted for 30 min．LVSP and dp／dtmax increased by 10％and 15％，respectively.The blood pressure.lowering effect could not be modified by atropine，while in rats pretreated with reserpine，CGRP decreased the mean blood pressure，LVSP and dp／dtmax significantly(P<0.01)with no change in heart rate．The results indicated that the involvement of the sympathetic were probably mediated by releasing transmitter of sympathetic nerves.

参考文献/References

［1］Rosenfeld GA,Amara SG,Mermod JJ.Production of anovel neuropeptide encode by the calcitonin gene via tissue-specific RNA processing．Nature 1983；304：129.

［2］Skofitch G，Jatobwitc DM．Quantitative distribution of calcitotfiil gone-related peptide in rat central nervous systenl．Peptides 1985；6：1069.

［3］Lappe RW，Todt JA，Wendt RL.Hemodynamic effect of calcitonin gene-related peptide in conSscious rats.Rrgul Pept 1 987；19：307.

［4］Dipette DJ，Rivier J，Morris R．Systenfic and regional hemodynanlic effects of calcitonin gene-related peptide.Hypertension 1987；9：Ⅲ142.

［5］Wimalawanas SJ．Regional and distribution of calcitonin gene-related peptide and its specific binding sites in rats with particular reference to the nervous system．Nauronedocrinology 1987；46：131.

［6］Hanko J，Hardebo JE，Kahrstrom J．Calcitonin gene-related peptide is preSent in mammalian cerebrovasular nerve fibers and dilates pial and peripheral arteries．Neurosci Lett 1985；57：91.

［7］Genmri C．CardiovaScular action of calcitonin gene-related peptide in human．Calcif Tissue Int 1 985；37：581.

备注/Memo

备注/Memo:
Receired 1993-08-28；revised 1994-01-04
更新日期/Last Update: 1995-01-01